CAS 20244-86-4|7-METHYLGUANOSINE

Introduction:Basic information about CAS 20244-86-4|7-METHYLGUANOSINE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name7-METHYLGUANOSINE
CAS Number20244-86-4Molecular Weight298.27500
Density/Boiling Point/
Molecular FormulaC11H16N5O5+Melting Point165ºC
MSDSUSAFlash Point/

Names

Name7-methylguanosine
SynonymMore Synonyms

7-METHYLGUANOSINE BiologicalActivity

Description7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 µM.
Related CatalogSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogResearch Areas >>Others
References

[1]. Kozarski M, et al. 7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase. Bioorg Med Chem. 2018 Jan 1;26(1):191-199.

Chemical & Physical Properties

Melting Point165ºC
Molecular FormulaC11H16N5O5+
Molecular Weight298.27500
Exact Mass298.11500
PSA150.50000
Index of Refraction1.86
InChIKeyOGHAROSJZRTIOK-XJCFNFQFSA-N
SMILESCn1c[n+](C2OC(CO)C(O)C2O)c2nc(N)nc([O-])c21
Storage condition−20°C

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety PhrasesS22-S24/25
RIDADRNONH for all modes of transport
WGK Germany3
HS Code2934999090

Customs

HS Code2934999090
Summary2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles8

More Articles
Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting.

J. Chromatogr. A. 1365 , 12-8, (2014)

A series of imprinted polymers targeting nucleoside metabolites, prepared using a template analogue approach, are presented. These were prepared following selection of the optimum functional monomer b...

Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity.

PLoS Genet. 11 , e1005586, (2015)

tRNA is the most highly modified class of RNA species, and modifications are found in tRNAs from all organisms that have been examined. Despite their vastly different chemical structures and their pre...

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.

Proc. Natl. Acad. Sci. U. S. A. 106 , 3484-3489, (2009)

The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to ca...

Synonyms

7-methlguanosine
N7-Methylguanosin
7-Methylguanosinium-Kation
7-Methylguanosine
2-amino-6,9-dihydro-7-methyl-6-oxo-9-1H-Purinium
7-methyl-guanosine
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