Introduction：Basic information about CAS 874908-14-2|3'-Hydroxy Repaglinide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 3'-Hydroxy Repaglinide |
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| CAS Number | 874908-14-2 | Molecular Weight | 468.58500 |
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| Density | 1.186g/cm3 | Boiling Point | 709.6ºC at 760 mmHg |
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| Molecular Formula | C27H36N2O5 | Melting Point | 79-82ºC |
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| MSDS | / | Flash Point | 383ºC |
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Names
| Name | 2-ethoxy-4-[2-[[1-[2-(3-hydroxypiperidin-1-yl)phenyl]-3-methylbutyl]amino]-2-oxoethyl]benzoic acid |
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3'-Hydroxy Repaglinide BiologicalActivity
| Description | 3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes[1][2]. |
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| Related Catalog | Research Areas >>Metabolic Disease |
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| References | [1]. A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probedrugs and their corresponding metabolites in human serum and urine. Anal Bioanal Chem. 2017 Jan;409(1):251-268. [2]. Honkalammi J, et al. Mechanism-based inactivation of CYP2C8 by gemfibrozil occurs rapidly in humans. Clin Pharmacol Ther. 2011 Apr;89(4):579-86. |
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Chemical & Physical Properties
| Density | 1.186g/cm3 |
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| Boiling Point | 709.6ºC at 760 mmHg |
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| Melting Point | 79-82ºC |
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| Molecular Formula | C27H36N2O5 |
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| Molecular Weight | 468.58500 |
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| Flash Point | 383ºC |
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| Exact Mass | 468.26200 |
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| PSA | 102.59000 |
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| LogP | 5.09600 |
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| Index of Refraction | 1.581 |
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| InChIKey | OBMAZJVHPAVADF-UHFFFAOYSA-N |
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| SMILES | CCOc1cc(CC(=O)NC(CC(C)C)c2ccccc2N2CCCC(O)C2)ccc1C(=O)O |
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| Storage condition | -20°C |
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