CAS 1156-19-0|Tolazamide

CHEMICAL IDENTIFICATION

RTECS NUMBER :

YT4400000

CHEMICAL NAME :

Urea, 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)-

CAS REGISTRY NUMBER :

1156-19-0

BEILSTEIN REFERENCE NO. :

1323565

LAST UPDATED :

199612

DATA ITEMS CITED :

6

MOLECULAR FORMULA :

C14-H21-N3-O3-S

MOLECULAR WEIGHT :

311.44

WISWESSER LINE NOTATION :

T7NTJ AMVMSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

256 mg/kg/3W-I

TOXIC EFFECTS :

Liver - jaundice, other or unclassified Liver - liver function tests impaired

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :

DNA damage

TEST SYSTEM :

Rodent - rat Liver

DOSE/DURATION :

4 mmol/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996