CAS 57757-57-0|DSP Crosslinker
| Common Name | DSP Crosslinker | ||
|---|---|---|---|
| CAS Number | 57757-57-0 | Molecular Weight | 404.415 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 560.1±60.0 °C at 760 mmHg |
| Molecular Formula | C14H16N2O8S2 | Melting Point | 128-133 °C |
| MSDS | ChineseUSA | Flash Point | 292.6±32.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3,3'-dithiodipropionic acid di(n-succinimidyl ester) |
|---|---|
| Synonym | More Synonyms |
DSP Crosslinker BiologicalActivity
| Description | DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Antibody-drug Conjugate >>ADC LinkerResearch Areas >>Inflammation/Immunology |
| Target | Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References | [1]. Zorea J, et al. Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor. Anal Bioanal Chem. 2020 Mar;412(7):1709-1717. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 560.1±60.0 °C at 760 mmHg |
| Melting Point | 128-133 °C |
| Molecular Formula | C14H16N2O8S2 |
| Molecular Weight | 404.415 |
| Flash Point | 292.6±32.9 °C |
| Exact Mass | 404.034790 |
| PSA | 177.96000 |
| LogP | -1.66 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.625 |
| InChIKey | FXYPGCIGRDZWNR-UHFFFAOYSA-N |
| SMILES | O=C(CCSSCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O |
| Storage condition | 2-8°C |
| Water Solubility | chloroform: 50 mg/mL |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| 2,5-Pyrrolidinedione, 1,1'-[dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis- |
| DSP |
| 1,1'-{Disulfanediylbis[(1-oxopropane-3,1-diyl)oxy]}dipyrrolidine-2,5-dione |
| MFCD00042045 |
| 1-((3-((3-((2,5-Dioxo-1-pyrrolidinyl)oxy)-3-oxopropyl)dithio)propanoyl)oxy)-2,5-pyrrolidinedione |
| Di(N-succinimidyl) 3,3'-dithiodipropionate |
| dithiobis(succinimidyl propionate) |
| 2,5-Pyrrolidinedione, 1,1'-(dithiobis((1-oxo-3,1-propanediyl)oxy))bis- |
| 1,1'-{Disulfanediylbis[(1-oxo-3,1-propanediyl)oxy]}di(2,5-pyrrolidinedione) |
| (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate |
| EINECS 260-931-5 |
