CAS 87-17-2|Salicylanilide
Introduction：Basic information about CAS 87-17-2|Salicylanilide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Salicylanilide | ||
|---|---|---|---|
| CAS Number | 87-17-2 | Molecular Weight | 213.232 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 294.3±23.0 °C at 760 mmHg |
| Molecular Formula | C13H11NO2 | Melting Point | 136-138 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 131.8±22.6 °C |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | salicylanilide |
|---|---|
| Synonym | More Synonyms |
Salicylanilide BiologicalActivity
| Description | Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>HIV IntegraseSignaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection |
| Target | HIV-1 integrase, reverse transcriptase[1] |
| In Vitro | Some Salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus is another virus, which can be potentially afflicted by Salicylanilides on the level of two enzymes-NS3 protease and NS5B RNA polymerase[1]. |
| References | [1]. Krátký M, et al. Antiviral activity of substituted salicylanilides--a review. Mini Rev Med Chem. 2011 Oct;11(11):956-67. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 294.3±23.0 °C at 760 mmHg |
| Melting Point | 136-138 °C(lit.) |
| Molecular Formula | C13H11NO2 |
| Molecular Weight | 213.232 |
| Flash Point | 131.8±22.6 °C |
| Exact Mass | 213.078979 |
| PSA | 49.33000 |
| LogP | 3.27 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.676 |
| InChIKey | WKEDVNSFRWHDNR-UHFFFAOYSA-N |
| SMILES | O=C(Nc1ccccc1)c1ccccc1O |
| Water Solubility | SLIGHTLY SOLUBLE |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,663,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 44,465,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82917 No. of Facilities: 178 (estimated) No. of Industries: 7 No. of Occupations: 5 No. of Employees: 837 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82917 No. of Facilities: 637 (estimated) No. of Industries: 10 No. of Occupations: 14 No. of Employees: 27279 (estimated) No. of Female Employees: 21161 (estimated)
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335-H400 |
| Precautionary Statements | P261-P273-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS | VN7850000 |
| HS Code | 29242995 |
Customs
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles27
More Articles| A closer study of peak distortions in supercritical fluid chromatography as generated by the injection. J. Chromatogr. A. 1400 , 131-9, (2015) In SFC the sample cannot be dissolved in the mobile phase, so it is often dissolved in pure modifier, or another liquid, sometimes resulting in serious distortions of the eluted peak profiles already ... | |
| Application of reactive salicylanilide to viscose fabrics as antibacterial and antifungus finishing. Int. J. Biol. Macromol. 50(1) , 273-6, (2012) In the present study salicylanilide was reacted with 2,4,6-trichloro-1,3,5-triazine producing reactive salicylanilide at a yield of 45% according to reaction conditions set. The reactive salicylanilid... | |
| Harmaline-resistant mutant of Methanothermobacter thermautotrophicus with a lesion in Na(+)/H(+) antiport. Gen. Physiol. Biophys. 30 Spec No , S54-60, (2011) A spontaneous mutant of Methanothermobacter thermautotrophicus resistant to the Na(+)/H(+) antiporter inhibitor harmaline was isolated. The Na(+)/H(+) exchange activity in the mutant cells was remarka... |
Synonyms
| 2-Phenylaminocarbonylphenol |
| Salinide |
| Benzamide, 2-hydroxy-N-phenyl- |
| Salicylanilid |
| 2-Hydroxy-N-phenylbenzamide |
| Salifebrin |
| Ansadol |
| salicylamide |
| salicylic acid anilide |
| N-Phenylsalicylamide |
| Hyanilid |
| EINECS 201-727-8 |
| 2-hydroxy-N-phenyl-benzamide |
| Aseptolan |
| Salicylanilide |
| MFCD00002212 |
