Introduction：Basic information about CAS 15981-92-7|2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one,2,3-dihydro-3-(hydroxymethyl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazepin-9-one,2,3-dihydro-3-(hydroxymethyl)-8-methyl-, (2R,3R,5R)- |
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| CAS Number | 15981-92-7 | Molecular Weight | 224.21 |
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| Density | 1.72g/cm3 | Boiling Point | 381.8ºC at 760mmHg |
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| Molecular Formula | C10H12N2O4 | Melting Point | 246-247ºC |
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| MSDS | USA | Flash Point | 184.7ºC |
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Names
| Name | 2,3'-anhydrothymidine |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | 2,3’-Anhydrothymidine; 2’-Deoxy-3’,2-anhydro-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
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| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
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Chemical & Physical Properties
| Density | 1.72g/cm3 |
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| Boiling Point | 381.8ºC at 760mmHg |
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| Melting Point | 246-247ºC |
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| Molecular Formula | C10H12N2O4 |
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| Molecular Weight | 224.21 |
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| Flash Point | 184.7ºC |
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| Exact Mass | 208.08500 |
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| PSA | 64.35000 |
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| Vapour Pressure | 2.12E-07mmHg at 25°C |
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| Index of Refraction | 1.735 |
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| InChIKey | JCSNHEYOIASGKU-UHFFFAOYSA-N |
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| SMILES | Cc1cn2c(nc1=O)OC1CC2OC1CO |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Articles2
More Articles
| [3'-(Tetrazol-2''-yl-3'-deoxythymidine and its 5''-substituted form: synthesis and conformation in the crystalline state. Substrate properties of 3'-(tetrazol-2''-yl)-3'-deoxythymidine-5'-triphosphate in relation to DNA polymerases]. Bioorg. Khim. 21 , 49-54, (1995) 5''-Derivatives of 3'-(tetrazole-2''-yl)-3'-deoxythymidines were synthesized by interaction of 5'-benzoyl-2',3'-anhydrothymidine with tetrazole or its 5-derivatives followed by debenzoylation. Structu... | |
| Study on disulfur-backboned nucleic acids: part 3. Efficient synthesis of 3',5'-dithio-2'-deoxyuridine and deoxycytidine. Nucleosides Nucleotides Nucleic Acids 27 , 1272-1281, (2008) A general method is described for synthesizing 3',5'-dithio-2'-deoxypyrimidine nucleosides 6 and 13 from normal 2'-deoxynucleosides. 2,3'-Anhydronucleosides 2 and 9 are applied as intermediates in the... | |
Synonyms
| 2,3'-Anhydro-D-thymidine |
| Anhydrothymidine |
| 2,3'-O-Cyclothymidine |
| 5-methyl-2'-deoxy-2,3'-anhydrouridine |
| threo-2,3'-anhydro-thymidine |
| O2,3'-Cyclothymidine |
