CAS 114607-46-4|acitazanolast

Introduction：Basic information about CAS 114607-46-4|acitazanolast, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. acitazanolast BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	acitazanolast
CAS Number	114607-46-4	Molecular Weight	233.184
Density	1.7±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₉H₇N₅O₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	2-oxo-2-[3-(2H-tetrazol-5-yl)anilino]acetic acid
Synonym	More Synonyms

acitazanolast BiologicalActivity

Description	Acitazanolast is an orally active antiallergic agent, can inhibit histamine release. Acitazanolast can be used in study of type I anaphylaxis (immediate) caused by IgE antibodies[1].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Molecular Formula	C₉H₇N₅O₃
Molecular Weight	233.184
Exact Mass	233.054886
PSA	120.86000
LogP	0.29
Index of Refraction	1.719
InChIKey	VWQZJJZGISNFOE-UHFFFAOYSA-N
SMILES	O=C(O)C(=O)Nc1cccc(-c2nn[nH]n2)c1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AJ1476901

CHEMICAL NAME :: Acetic acid, oxo-((3-(1H-tetrazol-5-yl)phenyl)amino)-

CAS REGISTRY NUMBER :: 114607-46-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H7-N5-O3

MOLECULAR WEIGHT :: 233.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1927 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Blood - normocytic anemia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Cardiac - arrhythmias (including changes in conduction) Gastrointestinal - nausea or vomiting

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,231,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22680 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in platelet count Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,107,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 28 gm/kg/4W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition Blood - normocytic anemia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,235,1995

Synonyms

MTCC

Oxo((3-(1H-tetrazol-5-yl)phenyl)amino)acetic Acid

acitazanolast

Oxo{[3-(2H-tetrazol-5-yl)phenyl]amino}acetic acid

Acetic acid, 2-oxo-2-[[3-(2H-tetrazol-5-yl)phenyl]amino]-

WP-871

Acitazanolast,WP-871

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