CAS 1428-95-1|5-(N,N-Hexamethylene)-amiloride
| Common Name | 5-(N,N-Hexamethylene)-amiloride | ||
|---|---|---|---|
| CAS Number | 1428-95-1 | Molecular Weight | 311.77100 |
| Density | 1.63g/cm3 | Boiling Point | 638.2ºC at 760mmHg |
| Molecular Formula | C12H18ClN7O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 339.8ºC |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | 5-(N,N-hexamethylene)amiloride |
|---|---|
| Synonym | More Synonyms |
5-(N,N-Hexamethylene)-amiloride BiologicalActivity
| Description | 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>CancerSignaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection |
| Target | Na+/H+ exchanger[1] EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2] |
| References | [1]. Rich IN, et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood. 2000 Feb 15;95(4):1427-34. [2]. Wilson L, et al. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep 30;353(2):294-306. Epub 2006 Jul 3. |
Chemical & Physical Properties
| Density | 1.63g/cm3 |
|---|---|
| Boiling Point | 638.2ºC at 760mmHg |
| Molecular Formula | C12H18ClN7O |
| Molecular Weight | 311.77100 |
| Flash Point | 339.8ºC |
| Exact Mass | 311.12600 |
| PSA | 136.51000 |
| LogP | 2.55300 |
| Vapour Pressure | 3.47E-16mmHg at 25°C |
| Index of Refraction | 1.742 |
| InChIKey | RQQJJXVETXFINY-UHFFFAOYSA-N |
| SMILES | NC(N)=NC(=O)c1nc(Cl)c(N2CCCCCC2)nc1N |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H311-H331 |
| Precautionary Statements | P261-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Phrases | 23/24/25 |
| Safety Phrases | 22-36/37/39-45 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| HMA |
| 3-amino-5-azepan-1-yl-6-chloro-pyrazine-2-carboxylic acid carbamimidoylamide |
| HMA-5 |
| 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide |
| Hexamethyleneamiloride |
