Introduction：Basic information about CAS 519055-63-1|Tasisulam sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tasisulam sodium |
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| CAS Number | 519055-63-1 | Molecular Weight | 437.09200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C11H5BrCl2NNaO3S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | sodium,(5-bromothiophen-2-yl)sulfonyl-(2,4-dichlorobenzoyl)azanide |
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| Synonym | More Synonyms |
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Tasisulam sodium BiologicalActivity
| Description | Tasisulam sodium (LY 573636 sodium) is a small molecule antitumor agent that inhibits mitotic progression and induces vascular normalization. Tasisulam sodium induces apoptosis via the intrinsic pathway[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| In Vitro | Tasisulam sodium (200 μM-200 nM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam sodium (200 μM-200 nM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Cell Proliferation Assay[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced an antiproliferative response across a wide range of tumor histologies with EC50s is 10 μM and 25 μM, respectively. Cell Cycle Analysis[1] Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 μM Incubation Time: 72 hours Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1] Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 μM-200 nM Incubation Time: 48 hours Result: Induced apoptosis in a broad range of in vitro cancer cell models. |
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| References | [1]. Meier T, et al. Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization. Mol Cancer Ther. 2011 Nov;10(11):2168-78. |
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Chemical & Physical Properties
| Molecular Formula | C11H5BrCl2NNaO3S2 |
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| Molecular Weight | 437.09200 |
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| Exact Mass | 434.81700 |
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| PSA | 106.18000 |
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| LogP | 5.46420 |
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| InChIKey | JCOHXVDKRMWUQP-UHFFFAOYSA-M |
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| SMILES | O=C([N-]S(=O)(=O)c1ccc(Br)s1)c1ccc(Cl)cc1Cl.[Na+] |
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Synonyms
| Tasisulam sodium |
| Tasisulam sodium (USAN) |
