CAS 70539-42-3|EGNHS

Introduction：Basic information about CAS 70539-42-3|EGNHS, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. EGNHS BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles38
6. Synonyms

Common Name	EGNHS
CAS Number	70539-42-3	Molecular Weight	456.35800
Density	1.52g/cm3	Boiling Point	603.4ºC at 760 mmHg
Molecular Formula	C₁₈H₂₀N₂O₁₂	Melting Point	/
MSDS	USA	Flash Point	318.7ºC

Names

Name	4-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutanoyl]oxyethyl] butanedioate
Synonym	More Synonyms

EGNHS BiologicalActivity

Description	EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density	1.52g/cm3
Boiling Point	603.4ºC at 760 mmHg
Molecular Formula	C₁₈H₂₀N₂O₁₂
Molecular Weight	456.35800
Flash Point	318.7ºC
Exact Mass	456.10200
PSA	179.96000
Index of Refraction	1.56
InChIKey	QLHLYJHNOCILIT-UHFFFAOYSA-N
SMILES	O=C(CCC(=O)ON1C(=O)CCC1=O)OCCOC(=O)CCC(=O)ON1C(=O)CCC1=O

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

Articles38

Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1.

Oncotarget 6 , 36338-53, (2015)

The mitochondrial accumulation of ATF2 is involved in tumor suppressor activities via cytochrome c release in melanoma cells. However, the signaling pathways that connect mitochondrial ATF2 accumulati...

Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia.

Epigenetics Chromatin 8 , 53, (2015)

Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and tran...

Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B.

J. Biol. Chem. 290 , 28329-42, (2015)

Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes. Here, we report that transcriptional ...

Synonyms

EGS

MFCD00049057

Peg-SS

EGBSS

Recommended......