CAS 156-38-7|4-Hydroxyphenylacetic acid
Introduction：Basic information about CAS 156-38-7|4-Hydroxyphenylacetic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Hydroxyphenylacetic acid | ||
|---|---|---|---|
| CAS Number | 156-38-7 | Molecular Weight | 152.147 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 346.6±17.0 °C at 760 mmHg |
| Molecular Formula | C8H8O3 | Melting Point | 148-151 °C(lit.) |
| MSDS | USA | Flash Point | 177.6±17.4 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 4-hydroxyphenylacetic acid |
|---|---|
| Synonym | More Synonyms |
4-Hydroxyphenylacetic acid BiologicalActivity
| Description | 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>NF-κB >>Keap1-Nrf2Natural Products >>PhenolsResearch Areas >>Metabolic Disease |
| Target | Nrf2[1] |
| In Vivo | 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1[1]. |
| References | [1]. Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 346.6±17.0 °C at 760 mmHg |
| Melting Point | 148-151 °C(lit.) |
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.147 |
| Flash Point | 177.6±17.4 °C |
| Exact Mass | 152.047348 |
| PSA | 57.53000 |
| LogP | 0.77 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.596 |
| InChIKey | XQXPVVBIMDBYFF-UHFFFAOYSA-N |
| SMILES | O=C(O)Cc1ccc(O)cc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,286,1958
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AI2680000 |
| HS Code | 2918290000 |
Customs
| HS Code | 2918290000 |
|---|---|
| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| 4-Hydroxyphenyl acetic acid |
| 2-(4-Hydroxyphenyl)acetic acid |
| 4-hydroxyphenylacetic acid |
| (p-hydroxyphenyl)-Acetic acid |
| (4-Hydroxy-phenyl)-acetic acid |
| 4-Hydroxy-Benzeneacetic acid |
| (4-Hydroxyphenyl)acetic acid |
| MFCD00004347 |
| Benzeneacetic acid, 4-hydroxy- |
| EINECS 205-851-3 |
| PHPA |
