Introduction：Basic information about CAS 15687-41-9|Oxyfedrine HCl, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxyfedrine HCl |
|---|
| CAS Number | 15687-41-9 | Molecular Weight | 349.85200 |
|---|
| Density | 1.122 g/cm3 | Boiling Point | 475.2ºC at 760 mmHg |
|---|
| Molecular Formula | C19H24ClNO3 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 241.2ºC |
|---|
Names
| Name | Oxyfedrine |
|---|
| Synonym | More Synonyms |
|---|
Oxyfedrine HCl BiologicalActivity
| Description | Oxyfedrine, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine can be used in the research of cardiovascular disease[1][2]. |
|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
|---|
| Target | β-adrenoceptor |
|---|
| In Vitro | Oxyfedrine (50 μM, 48 h) suppresses aldehyde dehydrogenase (ALDH) activity in HCT116 and HSC-4 cells[1]. Oxyfedrine (50 μM, 48 h) acts as a sensitizer for GSH-depleting agents, and induces cell death in HCT116 and HSC-4 cells when with the drug combinations[1]. Oxyfedrine (0-1 μg/mL) inhibits spontaneous myogenic activity in rat isolated portal vein[4]. |
|---|
| In Vivo | Oxyfedrine (14 mg/kg, p.o., for 3-4 weeks) shows anti-anginal action in cats[2]. Oxyfedrine (10 mg/kg, i.p., HCT116 cell xenograft mice) suppresses tumor growth when combined with sulfasalazine (SSZ, 350 mg/kg, i.p.)[1]. Oxyfedrine (1 mg/kg, i.v.) decreases the arterial and venous blood high blood viscosity (HBV) in ice water stress rats[3]. Animal Model: Cats[2] Dosage: 14 mg/kg Administration: Oral administration (p.o.), for 3-4 weeks. Result: Decreased systolic and diastolic blood pressures, increased heart rate and cardiac output. |
|---|
Chemical & Physical Properties
| Density | 1.122 g/cm3 |
|---|
| Boiling Point | 475.2ºC at 760 mmHg |
|---|
| Molecular Formula | C19H24ClNO3 |
|---|
| Molecular Weight | 349.85200 |
|---|
| Flash Point | 241.2ºC |
|---|
| Exact Mass | 349.14400 |
|---|
| PSA | 58.56000 |
|---|
| LogP | 4.17260 |
|---|
| Vapour Pressure | 7.78E-10mmHg at 25°C |
|---|
| Index of Refraction | 1.566 |
|---|
| InChIKey | GDYUVHBMFVMBAF-LIRRHRJNSA-N |
|---|
| SMILES | COc1cccc(C(=O)CCNC(C)C(O)c2ccccc2)c1 |
|---|
Synonyms
| 3-[[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]amino]-1-(3-methoxyphenyl)-1-propanone |
| (r-(r*,s*))-3-((2-hydroxy-1-methyl-2-phenylethyl)amino)-1-( 3-methoxyphenyl)-1-propanone |
| 3-{[(1S,2R)-2-Hydroxy-1-methyl-2-phenylethyl]amino}-1-[3-(methyloxy)phenyl]propan-1-one |
