CAS 110488-70-5|dimethomorph

Introduction：Basic information about CAS 110488-70-5|dimethomorph, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. dimethomorph BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles25
7. Synonyms

Common Name	dimethomorph
CAS Number	110488-70-5	Molecular Weight	387.857
Density	1.2±0.1 g/cm3	Boiling Point	584.9±50.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₂ClNO₄	Melting Point	125-149ºC
MSDS	ChineseUSA	Flash Point	307.5±30.1 °C
Symbol	GHS09	Signal Word

Names

Name	dimethomorph
Synonym	More Synonyms

dimethomorph BiologicalActivity

Description	Dimethomorph is a morpholine fungicide that inhibits fungal cell wall formation. Dimethomorph inhibits mycelial growth of the oomycete fungi P. citrophthora, P. parasitica, P. capsici, and P. infestans (EC50s=0.14 µg/mL, 0.38 µg/mL, <0.1 µg/mL, and 0.16-0.3 µg/mL, respectively) but is less active against the green algae species C. vulgaris or S. obliquus in vitro (EC50s=47.46 µg/mL and 44.87 µg/mL, respectively). Dimethomorph inhibits androgen receptor (AR) activity in a reporter assay in MDA-kb2 human breast cancer cells but not in a yeast antiandrogen screen (IC20s=0.263 µM and 38.5 µM, respectively).
Related Catalog	Signaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Others >>Androgen Receptor

Description

Dimethomorph is a morpholine fungicide that inhibits fungal cell wall formation. Dimethomorph inhibits mycelial growth of the oomycete fungi P. citrophthora, P. parasitica, P. capsici, and P. infestans (EC50s=0.14 µg/mL, 0.38 µg/mL, <0.1 µg/mL, and 0.16-0.3 µg/mL, respectively) but is less active against the green algae species C. vulgaris or S. obliquus in vitro (EC50s=47.46 µg/mL and 44.87 µg/mL, respectively). Dimethomorph inhibits androgen receptor (AR) activity in a reporter assay in MDA-kb2 human breast cancer cells but not in a yeast antiandrogen screen (IC20s=0.263 µM and 38.5 µM, respectively).

Related Catalog

Signaling Pathways >>Anti-infection >>FungalSignaling Pathways >>Others >>Androgen Receptor

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	584.9±50.0 °C at 760 mmHg
Melting Point	125-149ºC
Molecular Formula	C₂₁H₂₂ClNO₄
Molecular Weight	387.857
Flash Point	307.5±30.1 °C
Exact Mass	387.123749
PSA	48.00000
LogP	3.71
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.581
InChIKey	QNBTYORWCCMPQP-UHFFFAOYSA-N
SMILES	COc1ccc(C(=CC(=O)N2CCOCC2)c2ccc(Cl)cc2)cc1OC
Storage condition	0-6°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QE0478300

CHEMICAL NAME :: Morpholine, 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2 -propenyl)-

CAS REGISTRY NUMBER :: 110488-70-5

LAST UPDATED :: 199204

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H22-Cl-N-O4

MOLECULAR WEIGHT :: 387.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >4200 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,296,1991

Safety Information

Symbol	GHS09
Hazard Statements	H411
Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	N:Dangerousfortheenvironment;
Risk Phrases	R51/53
Safety Phrases	S61
RIDADR	UN3077 9/PG 3
RTECS	QE0478300
Packaging Group	III

Articles25

A molecularly imprinted polymer for the selective solid-phase extraction of dimethomorph from ginseng samples.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 988 , 182-186, (2015)

A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract dimethomorph from ginseng samples. Dimethomorph molecularly imprinted polymers with template to monomer molar...

Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens.

Environ. Health Perspect. 119 , 794-800, (2011)

Evidence suggests that there is widespread decline in male reproductive health and that antiandrogenic pollutants may play a significant role. There is also a clear disparity between pesticide exposur...

Competitive androgen receptor antagonism as a factor determining the predictability of cumulative antiandrogenic effects of widely used pesticides.

Environ. Health Perspect. 120 , 1578-84, (2012)

Many pesticides in current use have recently been revealed as in vitro androgen receptor (AR) antagonists, but information about their combined effects is lacking.We investigated the combined effects ...

Synonyms

ACROBAT

(2Ξ)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-(morpholin-4-yl)prop-2-en-1-one

MFCD01632781

Dimethoroph

4-[3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propen-1-yl]morpholine

(2E)-3-(4-Chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-(morpholin-4-yl)prop-2-en-1-one

2-Propen-1-one, 3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-(4-morpholinyl)-, (2E)-

CME 151

Akrobat

(2E)-3-(4-Chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-(4-morpholinyl)-2-propen-1-one

Forum

dimethomoph

EINECS 404-200-2

(2E)-3-(4-Chlorphenyl)-3-(3,4-dimethoxyphenyl)-1-(morpholin-4-yl)prop-2-en-1-on

(EZ)-4-[3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl]morpholine

morpholine, 4-[(2E)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]-

Festival C

Z-DIMETHOMORPH

AcrobatWP

4-[(2E)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]morpholine

Dimethomorph

3-(4-Chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-morpholinoprop-2-en-1-one

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