CAS 75790-53-3|Dynorphin A (1-8)

Introduction：Basic information about CAS 75790-53-3|Dynorphin A (1-8), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dynorphin A (1-8) BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Dynorphin A (1-8)
CAS Number	75790-53-3	Molecular Weight	981.15200
Density	1.38g/cm3	Boiling Point	/
Molecular Formula	C₄₆H₇₂N₁₄O₁₀	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Dynorphin A (1-8), porcine,YGGFLRRI
Synonym	More Synonyms

Dynorphin A (1-8) BiologicalActivity

Description	Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease
References	[1]. Agbas A, Ahmed MS, Millington W, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627. [2]. Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871.

Description

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease

References

[1]. Agbas A, Ahmed MS, Millington W, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627.

[2]. Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871.

Chemical & Physical Properties

Density	1.38g/cm3
Molecular Formula	C₄₆H₇₂N₁₄O₁₀
Molecular Weight	981.15200
Exact Mass	980.55600
PSA	411.05000
LogP	3.68290
Index of Refraction	1.637
InChIKey	WRPLGMBDXVBPEG-ZFBBIHQWSA-N
SMILES	CCC(C)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)O

Safety Information

WGK Germany	3

Synonyms

dynorphin A fragment 1-8

DYNORPHIN A (1-8),PORCINE

DYNORPHIN A PORCINE FRAGMENT 1-8

Ph-8p

GFL PEPTIDE STANDARD

dynorphin A (1-8)

H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-OH

YGGFLRRI

TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE

dynorphin-(1-8)

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