CAS 99588-52-0|H-Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2

Introduction：Basic information about CAS 99588-52-0|H-Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	H-Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2
CAS Number	99588-52-0	Molecular Weight	1920.13000
Density	/	Boiling Point	/
Molecular Formula	C₈₉H₁₃₀N₂₄O₂₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	H-Ala-Gly-Glu-Gly-Leu-Ser-Ser-Pro-Phe-Trp-Ser-Leu-Ala-Ala-Pro-Gln-Arg-Phe-NH2
Synonym	More Synonyms

BiologicalActivity

Description	Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects[1][2].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neuropeptide Y Receptor
In Vitro	Neuropeptide AF (NPAF) (50, 100, 150, 300, and 600nM) induces a piecemeal degranulation in bone marrow-derived mucosal mast cells (BMMCs). Neuropeptide AF can be considered as a novel modulator of BMMC activity in the neuro-immune communication in the gastrointestinal tract[1].
In Vivo	Neuropeptide AF (cattle) (0.25 μg/2 μL; i.c.v.; 30 min prior to the tests) decreases the immobility time and increases the climbing and swimming times in modified mouse forced swimming test (mFST)[2]. Animal Model: Male CFLP mice (25-28 g)[2] Dosage: 0.25 μg/2 μL Administration: i.c.v.; 30 min prior to the tests Result: Decreased the immobility time and increased the climbing and swimming times.
References	[1]. Nada Abdellah, et al. Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria? Anat Rec (Hoboken). 2018 Jun;301(6):1103-1114. [2]. Miklós Palotai, et al. Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice. Behav Brain Res. 2014 Nov 1;274:264-9.

Chemical & Physical Properties

Molecular Formula	C₈₉H₁₃₀N₂₄O₂₄
Molecular Weight	1920.13000
Exact Mass	1918.97000
PSA	765.00000
LogP	1.07870
InChIKey	GNNFMZHECHAEGF-IHFUZBNMSA-N
SMILES	CC(C)CC(NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)CNC(=O)C(C)N)C(=O)NC(CO)C(=O)NC(CO)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(N)=O

Synonyms

ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE-NH2

ALA-GLY-GLU-GLY-LEU-SER-SER-PRO-PHE-TRP-SER-LEU-ALA-ALA-PRO-GLN-ARG-PHE AMIDE

A18Famide

A-18-F-NH2

MFCD00076703

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