CAS 1464-53-5|2,2′-bioxirane

Introduction：Basic information about CAS 1464-53-5|2,2′-bioxirane, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Customs
6. Articles27
7. Synonyms

Common Name	2,2′-bioxirane
CAS Number	1464-53-5	Molecular Weight	86.089
Density	1.4±0.1 g/cm3	Boiling Point	138.0±0.0 °C at 760 mmHg
Molecular Formula	C₄H₆O₂	Melting Point	2-4 °C(lit.)
MSDS	USA	Flash Point	45.6±0.0 °C
Symbol	GHS02, GHS05, GHS06, GHS08	Signal Word	Danger

Names

Name	diepoxybutane
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	138.0±0.0 °C at 760 mmHg
Melting Point	2-4 °C(lit.)
Molecular Formula	C₄H₆O₂
Molecular Weight	86.089
Flash Point	45.6±0.0 °C
Exact Mass	86.036781
PSA	25.06000
LogP	-0.52
Vapour Pressure	8.5±0.2 mmHg at 25°C
Index of Refraction	1.546

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ8225000

CAS REGISTRY NUMBER :: 1464-53-5

BEILSTEIN REFERENCE NO. :: 0079833

LAST UPDATED :: 199806

DATA ITEMS CITED :: 80

MOLECULAR FORMULA :: C4-H6-O2

MOLECULAR WEIGHT :: 86.10

WISWESSER LINE NOTATION :: T3OTJ B- BT3OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 89 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 ppm/6H/6W-I

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg/10D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 ppm/6H/6W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - ulcerated nasal septum Lungs, Thorax, or Respiration - dyspnea Blood - changes in other cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 380 mg/kg/13W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Musculoskeletal - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 95 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease Skin and Appendages - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Heritable translocation test

TYPE OF TEST :: Dominant lethal test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Mutation in mammalian somatic cells

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 10 mmol/L

REFERENCE :: BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year: 138,611,1967 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993

Safety Information

Symbol	GHS02, GHS05, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H226-H301-H310 + H330-H314-H340-H350
Precautionary Statements	P201-P260-P280-P284-P301 + P310-P302 + P350
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T+: Very toxic;
Risk Phrases	R34;R45;R46;R24/25
Safety Phrases	S53-S45
RIDADR	UN 3384 6.1/PG 1
WGK Germany	1
RTECS	EJ8225000
Packaging Group	II
Hazard Class	6.1
HS Code	2910900090

Customs

HS Code	2910900090
Summary	2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles27

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.

Nat. Commun. 5 , 4330, (2014)

Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not ...

DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells.

Mutat. Res. 747(2) , 240-5, (2012)

1,3-Butadiene (BD) is a carcinogenic air pollutant. Its bioactivation produces four major metabolites, i.e., 3,4-epoxy-1-butene (EB), 3,4-epoxy-1,2-butanediol (EBD), 1,2,3,4-diepoxybutane (DEB), and 3...

Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells.

Mutat. Res. 684(1-2) , 35-42, (2010)

The primary function of O(6)-alkylguanine-DNA alkyltransferase (AGT) is to maintain genomic integrity in the face of damage by both endogenous and exogenous alkylating agents. However, paradoxically, ...

Synonyms

EINECS 215-979-1

DL-DIEPOXYBUTANE

MFCD00005120

2,2′-bioxirane

1,2:3,4-Diepoxybutane

DL-Erythritol anhydride

Butadiene diepoxide

1,3-Butadiene diepoxide

dl-1,2:3,4-Diepoxybutane

1,2,3,4-Diepoxybutane

dl-Butadiene dioxide

2,2'-Bioxirane

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