CAS 51857-17-1|NH2-C6-NH-Boc
Introduction：Basic information about CAS 51857-17-1|NH2-C6-NH-Boc, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NH2-C6-NH-Boc | ||
|---|---|---|---|
| CAS Number | 51857-17-1 | Molecular Weight | 216.320 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 325.3±25.0 °C at 760 mmHg |
| Molecular Formula | C11H24N2O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 150.5±23.2 °C |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | N-tert-Butoxycarbonyl-1,6-hexanediamine |
|---|---|
| Synonym | More Synonyms |
NH2-C6-NH-Boc BiologicalActivity
| Description | NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| References | [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 325.3±25.0 °C at 760 mmHg |
| Molecular Formula | C11H24N2O2 |
| Molecular Weight | 216.320 |
| Flash Point | 150.5±23.2 °C |
| Exact Mass | 216.183777 |
| PSA | 64.35000 |
| LogP | 1.82 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.460 |
| InChIKey | RVZPDKXEHIRFPM-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCCCCCN |
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | C:Corrosive; |
| Risk Phrases | R34 |
| Safety Phrases | S26-S36/37/39-S45 |
| RIDADR | UN 2735 8/PG 2 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 8 |
| HS Code | 2924199090 |
Customs
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles3
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| O. Buchardt et al. J. Org. Chem. 49 , 4123, (1984) |
Synonyms
| N-(tert-Butoxycarbonyl)-1,6-diaminohexane |
| N-Boc-1,6-hexanediamine |
| tert-Butyl (6-aminohexyl)carbamate |
| N-Boc-1,6-Diaminohexane |
| N-(6-Aminohexyl)carbamic Acid tert-Butyl Ester |
| tert-butyl N-(6-aminohexyl)carbamate |
| Carbamic acid, N-(6-aminohexyl)-, 1,1-dimethylethyl ester |
| MFCD00671489 |
| 2-Methyl-2-propanyl (6-aminohexyl)carbamate |
| N-(tert-Butoxycarbonyl)-1,6-hexanediamine |
