CAS 70563-58-5|Herbimycin A

Introduction：Basic information about CAS 70563-58-5|Herbimycin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Herbimycin A BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles31
8. Synonyms

Common Name	Herbimycin A
CAS Number	70563-58-5	Molecular Weight	574.662
Density	1.2±0.1 g/cm3	Boiling Point	752.4±60.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₂N₂O₉	Melting Point	/
MSDS	ChineseUSA	Flash Point	408.8±32.9 °C

Names

Name	herbimycin
Synonym	More Synonyms

Herbimycin A BiologicalActivity

Description	Herbimycin A, an ansamycin antibiotic, acts as a Src family kinase inhibitor. Herbimycin A binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Herbimycin A inhibits Hsp90 and impairs recovery from heat shock. Herbimycin A exhibits antiangiogenic activity in endothelial cells in vitro.
Related Catalog	Signaling Pathways >>Anti-infection >>Bacterial

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	752.4±60.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₂N₂O₉
Molecular Weight	574.662
Flash Point	408.8±32.9 °C
Exact Mass	574.289001
PSA	152.48000
LogP	2.12
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.545
InChIKey	MCAHMSDENAOJFZ-GDYSMBPZSA-N
SMILES	COC1C=CC=C(C)C(=O)NC2=CC(=O)C=C(C2=O)C(OC)C(C)CC(OC)C(OC)C(C)C=C(C)C1OC(N)=O
Storage condition	−20°C
Water Solubility	DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LX8930000

CHEMICAL NAME :: Geldanamycin, 17-demethoxy-15-methoxy-11-O-methyl-, (15R)-

CAS REGISTRY NUMBER :: 70563-58-5

LAST UPDATED :: 199209

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H42-N2-O9

MOLECULAR WEIGHT :: 574.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 33,1114,1980

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	22-24/25-36-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LX8930000
HS Code	29419000

Customs

HS Code	29419000

Articles31

Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.

J. Nat. Prod. 76(9) , 1619-26, (2013)

Bacterial strains belonging to the class actinomycetes were isolated from the soil near a thermal vent of the Ruth Mullins coal fire (Appalachian Mountains of eastern Kentucky). High-resolution electr...

Herbimycin A inhibits cell growth with reversal of epithelial-mesenchymal transition in anaplastic thyroid carcinoma cells.

Biochem. Biophys. Res. Commun. 455(3-4) , 363-70, (2014)

We aimed to elucidate the effect of herbimycin A (HMA), a heat shock protein 90 inhibitor, on cell growth and epithelial-mesenchymal transition (EMT) in anaplastic thyroid carcinoma (ATC) cells. HMA i...

Effects of tyrosine kinase and phosphatase inhibitors on microtubules in Arabidopsis root cells.

Cell Biol. Int. 32(6) , 630-7, (2008)

To investigate the role of tyrosine phosphorylation/dephosphorylation processes in plant cells the morphology of Arabidopsis thaliana primary roots and the organization of cortical microtubules (MTs) ...

Synonyms

2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-[(aminocarbonyl)oxy]-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-, (4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-

herbimycin

MFCD00151702

Herbimycin A

(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-9-[(aminocarbonyl)oxy]-8,13,14,17-tetramethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione

(15R)-17-demethoxy-15-methoxy-11-O-methylgeldanamycin

(4E,6Z,8S,9S,10E,12S,13R,14S,16S,17R)-8,13,14,17-Tetramethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Recommended......