Introduction：Basic information about CAS 144348-08-3|Binodenoson, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Binodenoson |
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| CAS Number | 144348-08-3 | Molecular Weight | 391.42 |
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| Density | 1.76g/cm3 | Boiling Point | 765.6ºC at 760mmHg |
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| Molecular Formula | C17H25N7O4 | Melting Point | / |
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| MSDS | / | Flash Point | 416.8ºC |
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Names
| Name | 2-(cyclohexylmethylidenehydrazino)adenosine |
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| Synonym | More Synonyms |
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Binodenoson BiologicalActivity
| Description | Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adenosine Receptor |
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| In Vitro | Binodenoson (MRE-0470) (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram[1]. |
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| In Vivo | Binodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage[1]. |
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| References | [1]. Sullivan GW, et al. Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of meningitis: synergy with the type IV phosphodiesterase inhibitor, rolipram. J Infect Dis. 1999;180(5):1550-1560. [2]. Glover DK, et al. Pharmacological stress thallium scintigraphy with 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470). A novel, short-acting adenosine A2A receptor agonist. Circulation. 1996;94(7):1726-1732. |
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Chemical & Physical Properties
| Density | 1.76g/cm3 |
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| Boiling Point | 765.6ºC at 760mmHg |
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| Molecular Formula | C17H25N7O4 |
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| Molecular Weight | 391.42 |
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| Flash Point | 416.8ºC |
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| Exact Mass | 391.19700 |
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| PSA | 163.93000 |
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| LogP | 0.65220 |
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| Vapour Pressure | 0mmHg at 25°C |
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| Index of Refraction | 1.812 |
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| InChIKey | XJFMHMFFBSOEPR-DNZQAUTHSA-N |
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| SMILES | Nc1nc(NN=CC2CCCCC2)nc2c1ncn2C1OC(CO)C(O)C1O |
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Synonyms
| sha 174 |
| wrc 0470 |
| mre 0470 |
| sha 211 |
| binodenoson |
