Introduction：Basic information about CAS 3562-63-8|Megestrol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Megestrol |
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| CAS Number | 3562-63-8 | Molecular Weight | 342.472 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 500.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H30O3 | Melting Point | / |
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| MSDS | / | Flash Point | 270.5±26.6 °C |
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Names
| Name | megestrol |
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| Synonym | More Synonyms |
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Megestrol BiologicalActivity
| Description | Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1]. |
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| References | [1]. Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 500.4±50.0 °C at 760 mmHg |
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| Molecular Formula | C22H30O3 |
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| Molecular Weight | 342.472 |
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| Flash Point | 270.5±26.6 °C |
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| Exact Mass | 342.219482 |
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| PSA | 54.37000 |
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| LogP | 3.06 |
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| Vapour Pressure | 0.0±2.9 mmHg at 25°C |
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| Index of Refraction | 1.569 |
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| InChIKey | VXIMPSPISRVBPZ-NWUMPJBXSA-N |
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| SMILES | CC(=O)C1(O)CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC21C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TU4074500
- CHEMICAL NAME :
- Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
- CAS REGISTRY NUMBER :
- 3562-63-8
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C22-H20-O3
- MOLECULAR WEIGHT :
- 332.42
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg/15D-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport
- REFERENCE :
- SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 11(3),17,1991
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Synonyms
| MFCD01939877 |
| EINECS 222-628-6 |
| 17-Hydroxy-6-methyl-pregna-4,6-dien-3,20-dion |
| 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione |
| 4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE |
| Megestrol |
| Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- |
| 20-dione,17-hydroxy-6-methyl-pregna-6-diene-3 |
