Introduction：Basic information about CAS 53267-01-9|Cibenzoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cibenzoline |
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| CAS Number | 53267-01-9 | Molecular Weight | 262.34900 |
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| Density | 1.17 g/cm3 | Boiling Point | 449.2ºC |
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| Molecular Formula | C18H18N2 | Melting Point | 103-104° |
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| MSDS | / | Flash Point | 225.5ºC |
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Names
| Name | Cibenzoline |
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| Synonym | More Synonyms |
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Cibenzoline BiologicalActivity
| Description | Cibenzoline is a potent inhibitor of KATP channel with directly affecting the pore-forming Kir6.2 subunit rather than the SUR1 subunit. Cibenzoline is a class Ia antiarrhythmic drug. Cibenzoline has little anticholinergic activity. Cibenzoline markedly attenuate LVPG which has a close relationship with myocardial contractility decreasing. Cibenzoline has the potential for the research of hypertrophic obstructive cardiomyopathy[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| Target | KATP channel[1] |
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| References | [1]. Mukai E, et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun. 1998;251(2):477-481. [2]. Hamada M, et al. Class Ia antiarrhythmic drug cibenzoline: a new approach to the medical treatment of hypertrophic obstructive cardiomyopathy. Circulation. 1997;96(5):1520-1524. |
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Chemical & Physical Properties
| Density | 1.17 g/cm3 |
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| Boiling Point | 449.2ºC |
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| Melting Point | 103-104° |
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| Molecular Formula | C18H18N2 |
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| Molecular Weight | 262.34900 |
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| Flash Point | 225.5ºC |
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| Exact Mass | 262.14700 |
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| PSA | 24.39000 |
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| LogP | 2.75870 |
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| Index of Refraction | 1.655 |
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| InChIKey | IPOBOOXFSRWSHL-UHFFFAOYSA-N |
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| SMILES | c1ccc(C2(c3ccccc3)CC2C2=NCCN2)cc1 |
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Safety Information
Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Cibenzolinum [inn-latin] |
| UP 33-901 |
| Cibenzolinum |
| Exacor |
| 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1H-imidazole |
| Cibenzolina |
| Cibenol |
| 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1 H-imidazole |
| Ro 22-7796 |
| [15N]-Cibenzoline |
| Cifenline |
