CAS 553-53-7|Nicotinohydrazide

Introduction：Basic information about CAS 553-53-7|Nicotinohydrazide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nicotinohydrazide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles13
8. Synonyms

Common Name	Nicotinohydrazide
CAS Number	553-53-7	Molecular Weight	137.139
Density	1.2±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₆H₇N₃O	Melting Point	159-161 °C(lit.)
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	Nicotinohydrazide
Synonym	More Synonyms

Nicotinohydrazide BiologicalActivity

Description	Nicotinohydrazide (Nicotinic acid hydrazide) is a small molecular compound[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Kruszynski R. A structural and theoretical study of intermolecular interactions in nicotinohydrazide dihydrochloride. Acta Crystallogr C. 2011 Feb;67(Pt 2):o52-6.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Melting Point	159-161 °C(lit.)
Molecular Formula	C₆H₇N₃O
Molecular Weight	137.139
Exact Mass	137.058914
PSA	68.01000
LogP	-0.83
Index of Refraction	1.584
InChIKey	KFUSANSHCADHNJ-UHFFFAOYSA-N
SMILES	NNC(=O)c1cccnc1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT1750000

CHEMICAL NAME :: Nicotinic acid, hydrazide

CAS REGISTRY NUMBER :: 553-53-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H7-N3-O

MOLECULAR WEIGHT :: 137.16

WISWESSER LINE NOTATION :: T6NJ CVMZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04178

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,691,1955 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 124 gm/kg/71W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 38,106,1981

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R40
Safety Phrases	S22-S26-S36/37/39
RIDADR	UN2811
WGK Germany	3
RTECS	QT1750000
Packaging Group	III
Hazard Class	6.1
HS Code	2933399090

Customs

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles13

Controlled release studies of antimalarial 1, 3, 5-trisubstituted-2-pyrazolines from biocompatible chitosan-heparin Layer-by-Layer (LbL) self assembled thin films.

Colloids Surf. B Biointerfaces 125 , 151-9, (2015)

Herein we report the in-vitro controlled release properties of 1, 3, 5-trisubstituted-2-pyrazolines through Layer-by-Layer (LbL) self assembled thin films fabricated from chitosan and heparin sodium s...

Chemokine CCL17 induced by hypoxia promotes the proliferation of cervical cancer cell.

Am. J. Cancer Res. 5 , 3072-84, (2015)

Cervical cancer is often associated with hypoxia and many kinds of chemokines. But the relationship and role of hypoxia and Chemokine (C-C motif) ligand 17 (CCL17) in cervical cancer are still unknown...

Double-level "orthogonal" dynamic combinatorial libraries on transition metal template.

Proc. Natl. Acad. Sci. U. S. A. 98(4) , 1347-52, (2001)

Dynamic combinatorial libraries are mixtures of compounds that exist in a dynamic equilibrium and can be driven to compositional self adaptation via selective binding of a specific assembly of certain...

Synonyms

Nicotinohydrazide

pyridine-3-carbohydrazide

EINECS 209-041-0

MFCD00006383

3-Pyridinecarboxylic acid, hydrazide

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