CAS 119817-90-2|Dexloxiglumide

Introduction：Basic information about CAS 119817-90-2|Dexloxiglumide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dexloxiglumide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Dexloxiglumide
CAS Number	119817-90-2	Molecular Weight	461.37900
Density	1.233g/cm3	Boiling Point	632.2ºC at 760mmHg
Molecular Formula	C₂₁H₃₀Cl₂N₂O₅	Melting Point	/
MSDS	/	Flash Point	336.1ºC

Names

Name	(4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
Synonym	More Synonyms

Dexloxiglumide BiologicalActivity

Description	Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Cholecystokinin ReceptorResearch Areas >>Metabolic Disease
References	[1]. Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9. [2]. Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49(3):211-6.

Description

Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Cholecystokinin ReceptorResearch Areas >>Metabolic Disease

References

[1]. Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9.

[2]. Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49(3):211-6.

Chemical & Physical Properties

Density	1.233g/cm3
Boiling Point	632.2ºC at 760mmHg
Molecular Formula	C₂₁H₃₀Cl₂N₂O₅
Molecular Weight	461.37900
Flash Point	336.1ºC
Exact Mass	460.15300
PSA	95.94000
LogP	4.40280
Vapour Pressure	7.51E-17mmHg at 25°C
Index of Refraction	1.537
InChIKey	QNQZBKQEIFTHFZ-GOSISDBHSA-N
SMILES	CCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1

Safety Information

Hazard Codes	Xn,Xi

Synonyms

CR-2017

Dexloxiglumida [INN-Spanish]

Dexloxiglumidum [INN-Latin]

Dexloxiglumidum

Dexloxiglumida

Dexloxiglumide

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