Introduction：Basic information about CAS 86408-72-2|Ecabet sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ecabet sodium |
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| CAS Number | 86408-72-2 | Molecular Weight | 402.480 |
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| Density | 1.241 g/cm3 | Boiling Point | / |
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| Molecular Formula | C20H27NaO5S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Ecabet sodium |
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| Synonym | More Synonyms |
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Ecabet sodium BiologicalActivity
| Description | Ecabet sodium (TA-2711) is currently applied to some clinical gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication[1]. Ecabet sodium reduces apoptosis[2]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| Target | ROS production; Bacterial[1]; Apoptosis[2] |
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| References | [1]. Wang Y, et al. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81. [2]. Rah YC, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015 Dec;89:1176-83. |
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Chemical & Physical Properties
| Density | 1.241 g/cm3 |
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| Molecular Formula | C20H27NaO5S |
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| Molecular Weight | 402.480 |
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| Exact Mass | 402.147675 |
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| PSA | 102.88000 |
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| LogP | 4.88980 |
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| Index of Refraction | 1.562 |
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| InChIKey | NQQLQPVASUVBKM-MUMAJMNHSA-L |
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| SMILES | CC(C)c1cc2c(cc1S(=O)(=O)[O-])C1(C)CCCC(C)(C(=O)[O-])C1CC2.[Na+].[Na+] |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SF7312000
- CHEMICAL NAME :
- 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-meth ylethyl)- 6-sulfo-, (1R-(1-alpha,4a-beta,10a-alpha))-, monosodium salt
- CAS REGISTRY NUMBER :
- 86408-72-2
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C20-H28-O5-S.Na
- MOLECULAR WEIGHT :
- 403.53
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4529602 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 11 gm/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 25,941,1991
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Safety Information
Synonyms
| 12-sulfodehydroabietic acid 12-sodium salt pentahydrate |
| Ecabetsodiumsalt |
| Sodium 18-hydroxy-18-oxoabieta-8(14),9(11),12-triene-12-sulfonate |
| 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, sodium salt, (1R,4aS,10aR)- (1:1) |
| 1-Phenanthrenecarboxylic acid,1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-,monosodium salt,(1R,4aS,10aR) |
| Gastrom |
| 12-Sulfodehydroabietic acid monosodium salt |
| ta-2711 |
