CAS 119006-77-8|FLUTRIMAZOLE
Introduction：Basic information about CAS 119006-77-8|FLUTRIMAZOLE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | FLUTRIMAZOLE | ||
|---|---|---|---|
| CAS Number | 119006-77-8 | Molecular Weight | 346.373 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 457.1±40.0 °C at 760 mmHg |
| Molecular Formula | C22H16F2N2 | Melting Point | 161-166ºC |
| MSDS | / | Flash Point | 230.3±27.3 °C |
Names
| Name | flutrimazole |
|---|---|
| Synonym | More Synonyms |
FLUTRIMAZOLE BiologicalActivity
| Description | Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal |
| References | [1]. Merlos M, et al. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996;45(1):20-25. [2]. Ramis J, et al. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997;47(10):1139-1144. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 457.1±40.0 °C at 760 mmHg |
| Melting Point | 161-166ºC |
| Molecular Formula | C22H16F2N2 |
| Molecular Weight | 346.373 |
| Flash Point | 230.3±27.3 °C |
| Exact Mass | 346.128143 |
| PSA | 17.82000 |
| LogP | 4.95 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.590 |
| InChIKey | QHMWCHQXCUNUAK-UHFFFAOYSA-N |
| SMILES | Fc1ccc(C(c2ccccc2)(c2ccccc2F)n2ccnc2)cc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 808 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1079 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992
Articles20
More Articles| Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release cream (1, 2 and 4%) with placebo site-release vaginal cream. Mycoses 43(9-10) , 355-65, (2000) A double-blind randomized comparative phase II study of flutrimazole site-release vaginal cream (1, 2 and 4%) with placebo site-release vaginal cream was undertaken in patients with acute vulvovaginal... | |
| Efficacy of flutrimazole 1% powder in the treatment of tinea pedis. Mycoses 46(3-4) , 126-31, (2003) The aim of the study was to compare the efficacy and tolerability of flutrimazole 1% powder vs. bifonazole 1% powder in treating tinea pedis. A multicentre, double blind, randomized, parallel and comp... | |
| Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial. Mycoses 53(6) , 522-9, (2010) Fluconazole, which is a drug of the azole family, is safely used in systemic treatment of oral and intravenous injection, but it is difficult to use fluconazole as a topical application because of its... |
Synonyms
| Flutrimazolum |
| 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-Imidazol |
| Flutrimazole (INN) |
| FLUTRIMAZOLE |
| 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole |
| Micetal |
| Flutrimazolum [INN-Latin] |
| Flutrimazol [INN-Spanish] |
| 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole |
| MFCD00865591 |
| Flutrimazol |
| 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole |
| 1-[o-Fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole |
| 1H-Imidazole, 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]- |
| UR-4056 |
