CAS 53552-05-9|(-)-Bicuculline methochloride
Introduction：Basic information about CAS 53552-05-9|(-)-Bicuculline methochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (-)-Bicuculline methochloride | ||
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| CAS Number | 53552-05-9 | Molecular Weight | 417.84000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C21H20ClNO6 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 6-(6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl)-6H-furo[3,4-g][1,3]benzodioxol-8-one,chloride |
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(-)-Bicuculline methochloride BiologicalActivity
| Description | (-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
| Target | GABAA[1] |
| In Vivo | (-)-Bicuculline methochloride (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2]. Animal Model: Rat L5-SNL model[2] Dosage: 0.6 nmol/rat Administration: Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.) Result: Attenuated the antiallodynic effect of Neurotropin. |
| References | [1]. Seutin V, et al. Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci. 1999 Jul;20(7):268-70. [2]. Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107(3):1064-9. |
Chemical & Physical Properties
| Molecular Formula | C21H20ClNO6 |
|---|---|
| Molecular Weight | 417.84000 |
| Exact Mass | 417.09800 |
| PSA | 63.22000 |
| InChIKey | RLJKFAMYSYWMND-VOMIJIAVSA-M |
| SMILES | C[N+]1(C)CCc2cc3c(cc2C1C1OC(=O)c2c1ccc1c2OCO1)OCO3.[Cl-] |
