Introduction：Basic information about CAS 99632-94-7|RO 19-4603, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | RO 19-4603 |
|---|
| CAS Number | 99632-94-7 | Molecular Weight | 319.38 |
|---|
| Density | 1.37g/cm3 | Boiling Point | 537.7ºC at 760 mmHg |
|---|
| Molecular Formula | C15H17N3O3S | Melting Point | / |
|---|
| MSDS | / | Flash Point | 279ºC |
|---|
Names
| Name | tert.-butyl 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate |
|---|
| Synonym | More Synonyms |
|---|
RO 19-4603 BiologicalActivity
| Description | Ro19-4603 is a benzodiazepine inverse agonist. Ro19-4603 antagonizes ethanol (EtOH) intake in alcohol-preferring rats[1]. |
|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
|---|
| In Vivo | Ro19-4603 (0-0.3 mg/kg，腹腔注射) 显着降低嗜酒大鼠在 8 小时间隔内的乙醇摄入量[1]。 Animal Model: Alcohol-Preferring rats[1] Dosage: 0.075, 0.150, and 0.30 mg/kg. Administration: i.p. Result: Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval. |
|---|
| References | [1]. June HL, et al. The benzodiazepine inverse agonist RO19-4603 exerts prolonged and selective suppression of ethanol intake in alcohol-preferring (P) rats. Psychopharmacology (Berl). 1994 Jul;115(3):325-31. |
|---|
Chemical & Physical Properties
| Density | 1.37g/cm3 |
|---|
| Boiling Point | 537.7ºC at 760 mmHg |
|---|
| Molecular Formula | C15H17N3O3S |
|---|
| Molecular Weight | 319.38 |
|---|
| Flash Point | 279ºC |
|---|
| Exact Mass | 319.09900 |
|---|
| PSA | 92.67000 |
|---|
| LogP | 2.41260 |
|---|
| Index of Refraction | 1.659 |
|---|
| InChIKey | ZIGMMUKDYCABPW-UHFFFAOYSA-N |
|---|
| SMILES | CN1Cc2c(C(=O)OC(C)(C)C)ncn2-c2ccsc2C1=O |
|---|
Synonyms
