CAS 51116-01-9|8-Br-cGMP(8-Bromo-cGMP)
| Common Name | 8-Br-cGMP(8-Bromo-cGMP) | ||
|---|---|---|---|
| CAS Number | 51116-01-9 | Molecular Weight | 446.083 |
| Density | 2.96 g/cm3 | Boiling Point | 794.3ºC at 760 mmHg |
| Molecular Formula | C10H10BrN5NaO7P | Melting Point | / |
| MSDS | USA | Flash Point | 434.2ºC |
Names
| Name | 8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt |
|---|---|
| Synonym | More Synonyms |
8-Br-cGMP(8-Bromo-cGMP) BiologicalActivity
| Description | 8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator and significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+[1]. 8-Bromo-cGMP sodium has antinociceptive effects[2]. |
|---|---|
| Target | PKG, Ca2+[1] |
| References | [1]. Sarkar O , et al. Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling. PLoS One. 2017 Jul 10;12(7):e0179301. [2]. Tegeder I , et al. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett. 2002 Oct 31;332(2):146-50. |
Chemical & Physical Properties
| Density | 2.96 g/cm3 |
|---|---|
| Boiling Point | 794.3ºC at 760 mmHg |
| Molecular Formula | C10H10BrN5NaO7P |
| Molecular Weight | 446.083 |
| Flash Point | 434.2ºC |
| Exact Mass | 444.939880 |
| PSA | 187.45000 |
| LogP | 0.25780 |
| InChIKey | FJAOOACZDYDVJT-YEOHUATISA-N |
| SMILES | Nc1nc2c(nc(Br)n2C2OC3COP(=O)(O)OC3C2O)c(=O)[nH]1.[Na] |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles87
More Articles| Role of Telokin in Regulating Murine Gastric Fundus Smooth Muscle Tension. PLoS ONE 10 , e0134876, (2015) Telokin phosphorylation by cyclic GMP-dependent protein kinase facilitates smooth muscle relaxation. In this study we examined the relaxation of gastric fundus smooth muscles from basal tone, or pre-c... | |
| Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice. Br. J. Pharmacol. 171(24) , 5858-69, (2014) Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadi... | |
| Platelet-derived HMGB1 is a critical mediator of thrombosis. J. Clin. Invest. 125 , 4638-54, (2015) Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular coagulation and acute ischemic events. The damage-associated molecular patt... |
Synonyms
| 8-Br-cGMP 8-Bromo-cyclic GMP |
| EINECS 256-993-8 |
| sodium 8-bromo-3',5'-cyclic GMP |
| Sodium (4aR,6R,7R,7aS)-6-(2-amino-8-bromo-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide |
| 8-Bromo-cGMP, sodium salt,8-Bromoguanosinecyclic3',5'-monophosphatesodiumsalt |
| 6H-Purin-6-one, 2-amino-8-bromo-1,9-dihydro-9-[(4aR,6R,7R,7aS)-tetrahydro-2,7-dihydroxy-2-oxido-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-6-yl]-, sodium salt (1:1) |
| MFCD00070128 |
