CAS 123039-93-0|Dihydrexidine
Introduction：Basic information about CAS 123039-93-0|Dihydrexidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dihydrexidine | ||
|---|---|---|---|
| CAS Number | 123039-93-0 | Molecular Weight | 303.78300 |
| Density | 1.267g/cm3 | Boiling Point | 488.3ºC at 760mmHg |
| Molecular Formula | C17H17NO2 | Melting Point | / |
| MSDS | / | Flash Point | 190.5ºC |
Names
| Name | 5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol |
|---|---|
| Synonym | More Synonyms |
Dihydrexidine BiologicalActivity
| Description | Dihydrexidine (DAR-100) is a high potent, selective and full efficacy D1 dopamine receptor agonist with an IC50 of 10 nM, and displays some affinity for the D2 receptor. Dihydrexidine (DAR-100) exhibits potent antiparkinsonian activity[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
| Target | IC50: 10 nM (D1 dopamine receptor)[1] |
| References | [1]. Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3. [2]. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. [3]. Salmi P,et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42. |
Chemical & Physical Properties
| Density | 1.267g/cm3 |
|---|---|
| Boiling Point | 488.3ºC at 760mmHg |
| Molecular Formula | C17H17NO2 |
| Molecular Weight | 303.78300 |
| Flash Point | 190.5ºC |
| Exact Mass | 303.10300 |
| PSA | 52.49000 |
| LogP | 3.77850 |
| Vapour Pressure | 3.7E-10mmHg at 25°C |
| InChIKey | BGOQGUHWXBGXJW-UHFFFAOYSA-N |
| SMILES | Oc1cc2c(cc1O)C1c3ccccc3CNC1CC2 |
Synonyms
| dihydrexidine |
| dar0100a |
