Introduction：Basic information about CAS 140187-23-1|(S)-(-)-5-Fluorowillardiine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (S)-(-)-5-Fluorowillardiine |
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| CAS Number | 140187-23-1 | Molecular Weight | 217.15500 |
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| Density | 1.64 g/cm3 | Boiling Point | / |
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| Molecular Formula | C7H8FN3O4 | Melting Point | 235ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 3-(5-fluorouracil-1-yl)-L-alanine |
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| Synonym | More Synonyms |
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(S)-(-)-5-Fluorowillardiine BiologicalActivity
| Description | (S)-(-)-5-Fluorowillardiine is a potent and specific AMPAR agonist. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>iGluRSignaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological Disease |
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| References | [1]. Hawkinson JE, et al. Effects of thiocyanate and AMPA receptor ligands on (S)-5-fluorowillardiine, (S)-AMPA and (R,S)-AMPA binding. Eur J Pharmacol. 1997 Jun 25;329(2-3):213-21. [2]. Kessler M, et al. Use of [3H]fluorowillardiine to study properties of AMPA receptor allosteric modulators. Brain Res. 2006 Mar 3;1076(1):25-41. [3]. Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82. |
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Chemical & Physical Properties
| Density | 1.64 g/cm3 |
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| Melting Point | 235ºC |
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| Molecular Formula | C7H8FN3O4 |
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| Molecular Weight | 217.15500 |
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| Exact Mass | 217.05000 |
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| PSA | 118.18000 |
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| Index of Refraction | 1.601 |
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| InChIKey | DBWPFHJYSTVBCZ-BYPYZUCNSA-N |
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| SMILES | NC(Cn1cc(F)c(=O)[nH]c1=O)C(=O)O |
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| Storage condition | Store at RT |
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Synonyms
| 5-Fluorowillardiine |
| FLUORO-WILLARDIINE |
| Tocris-0306 |
| (2S)-2-amino-3-(5-fluoro-2,4-dioxopyrimidin-1-yl)propanoic acid |
| 1mqi |
| FWD |
| (S)-(-)-5-Fluorowillardiine |
