CAS 122955-42-4|XE 991 dihydrochloride

Introduction：Basic information about CAS 122955-42-4|XE 991 dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. XE 991 dihydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles3
6. Synonyms

Common Name	XE 991 dihydrochloride
CAS Number	122955-42-4	Molecular Weight	376.45
Density	/	Boiling Point	625.3ºC at 760mmHg
Molecular Formula	C₂₆H₂₀N₂O	Melting Point	/
MSDS	ChineseUSA	Flash Point	332ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
Synonym	More Synonyms

XE 991 dihydrochloride BiologicalActivity

Description	XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
References	[1]. Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Description

XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1].

Related Catalog

Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel

References

[1]. Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3.

[2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Chemical & Physical Properties

Boiling Point	625.3ºC at 760mmHg
Molecular Formula	C₂₆H₂₀N₂O
Molecular Weight	376.45
Flash Point	332ºC
Exact Mass	376.15800
PSA	42.85000
LogP	4.79250
Vapour Pressure	6.84E-16mmHg at 25°C
InChIKey	KHJFBUUFMUBONL-UHFFFAOYSA-N
SMILES	O=C1c2ccccc2C(Cc2ccncc2)(Cc2ccncc2)c2ccccc21
Storage condition	2-8°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
RTECS	CB1530000

Articles3

Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.

J. Neurosci. 35 , 11105-17, (2015)

Neuron-astrocyte interactions are critical for proper CNS development and function. Astrocytes secrete factors that are pivotal for synaptic development and function, neuronal metabolism, and neuronal...

Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus.

PLoS ONE 7 , e30402, (2012)

Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit...

Raised activity of L-type calcium channels renders neurons prone to form paroxysmal depolarization shifts.

Neuromolecular Med. 15 , 476-92, (2013)

Neuronal L-type voltage-gated calcium channels (LTCCs) are involved in several physiological functions, but increased activity of LTCCs has been linked to pathology. Due to the coupling of LTCC-mediat...

Synonyms

10,10-bis(pyridin-4-ylmethyl)anthracen-9-one,dihydrochloride

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