CAS 67869-62-9|GPRP
| Common Name | GPRP | ||
|---|---|---|---|
| CAS Number | 67869-62-9 | Molecular Weight | 425.48300 |
| Density | 1.55 g/cm3 | Boiling Point | / |
| Molecular Formula | C18H31N7O5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | gly-pro-arg-pro |
|---|---|
| Synonym | More Synonyms |
GPRP BiologicalActivity
| Description | GPRP (Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| References | [1]. Gallistl S, et al. Gly-pro-arg-pro (GPRP) enhances free thrombin. Thromb Res. 1995 Jun 15;78(6):547-50. [2]. Hsieh KH, et, al. Fibrin Polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J Med Chem. 1981 Mar; 24(3): 322-7. |
Chemical & Physical Properties
| Density | 1.55 g/cm3 |
|---|---|
| Molecular Formula | C18H31N7O5 |
| Molecular Weight | 425.48300 |
| Exact Mass | 425.23900 |
| PSA | 194.94000 |
| Index of Refraction | 1.691 |
| InChIKey | WXPZDDCNKXMOMC-AVGNSLFASA-N |
| SMILES | NCC(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)O |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles30
More Articles| Integrin-linked kinase regulates the rate of platelet activation and is essential for the formation of stable thrombi. J. Thromb. Haemost. 12(8) , 1342-52, (2014) Integrin-linked kinase (ILK) and its associated complex of proteins are involved in many cellular activation processes, including cell adhesion and integrin signaling. We have previously demonstrated ... | |
| Platelet function tests, independent of platelet count, are associated with bleeding severity in ITP. Blood 126 , 873-9, (2015) Immune thrombocytopenia (ITP) patients with similarly low platelet counts differ in their tendency to bleed. To determine if differences in platelet function in ITP patients account for this variation... | |
| Procoagulant platelets form an α-granule protein-covered "cap" on their surface that promotes their attachment to aggregates. J. Biol. Chem. 288(41) , 29621-32, (2013) Strongly activated "coated" platelets are characterized by increased phosphatidylserine (PS) surface expression, α-granule protein retention, and lack of active integrin αIIbβ3. To study how they are ... |
Synonyms
| glycine-proline-arginine-proline |
| FIBRINOLYSIS INHIBITNG FACTOR |
| LAUDANO-DOOLITTLE PEPTIDE |
| GPRP FIBRIN ANTIPOLYMERANT |
| GPRP |
| glycyl-L-prolyl-L-arginyl-L-prolin |
| MFCD00133378 |
| glycyl-prolyl-arginyl-proline |
| FIBRINOLYSIS INHIBITING FACTOR |
| M.W. 425.49 C18H31N7O5 |
