CAS 704888-90-4|ARP-100
Introduction：Basic information about CAS 704888-90-4|ARP-100, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ARP-100 | ||
|---|---|---|---|
| CAS Number | 704888-90-4 | Molecular Weight | 364.416 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C17H20N2O5S | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide |
|---|---|
| Synonym | More Synonyms |
ARP-100 BiologicalActivity
| Description | ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM)[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>MMP |
| Target | MMP-2:12 nM (IC50) MMP-9:0.2 μM (IC50) MMP-3:4.5 μM (IC50) MMP-1:>50 μM (IC50) MMP-7:>50 μM (IC50) |
| In Vitro | ARP-100 (50 nM) shows a significant reduction in the total number of invasive elongations[1]. |
| References | [1]. Rossello A, et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorg Med Chem. 2004 May 1;12(9):2441-50. [2]. Tuccinardi T, et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C17H20N2O5S |
| Molecular Weight | 364.416 |
| Exact Mass | 364.109283 |
| PSA | 104.32000 |
| LogP | 2.08 |
| Index of Refraction | 1.589 |
| InChIKey | PHGLPDURIUEELR-UHFFFAOYSA-N |
| SMILES | CC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(-c2ccccc2)cc1 |
Safety Information
| HS Code | 2935009090 |
|---|
Customs
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
Synonyms
| MMP-2 Inhibitor III |
| ARP 100 |
| N-(4-Biphenylylsulfonyl)-N-hydroxy-N-isopropoxyglycinamide |
| N-(biphenyl-4-ylsulfonyl)-N-hydroxy-N-(propan-2-yloxy)glycinamide |
| Acetamide, 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy- |
