CAS 73029-73-9|CyPPA

Introduction：Basic information about CAS 73029-73-9|CyPPA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CyPPA BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles2
7. Synonyms

Common Name	CyPPA
CAS Number	73029-73-9	Molecular Weight	285.387
Density	1.2±0.1 g/cm3	Boiling Point	512.2±42.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₃N₅	Melting Point	/
MSDS	ChineseUSA	Flash Point	263.6±27.9 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
Synonym	More Synonyms

CyPPA BiologicalActivity

Description	CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
In Vitro	CyPPA induces a concentration-dependent increase in the apparent Ca2+-sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM[1].
In Vivo	CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice[2].
References	[1]. Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Br J Pharmacol. 2007 Jul;151(5):655-65. [2]. Dana V Skarra, et al. CyPPA, a positive modulator of small-conductance Ca(2+)-activated K(+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1027-35.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	512.2±42.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₃N₅
Molecular Weight	285.387
Flash Point	263.6±27.9 °C
Exact Mass	285.195343
PSA	55.63000
LogP	2.13
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.648
InChIKey	USEMRPYUFJNFQN-UHFFFAOYSA-N
SMILES	Cc1cc(NC2CCCCC2)nc(-n2nc(C)cc2C)n1
Storage condition	2-8℃

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335-H413
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles2

Duration differences of corticostriatal responses in striatal projection neurons depend on calcium activated potassium currents.

Front. Syst. Neurosci. 7 , 63, (2013)

The firing of striatal projection neurons (SPNs) exhibits afterhyperpolarizing potentials (AHPs) that determine discharge frequency. They are in part generated by Ca(2+)-activated K(+)-currents involv...

Identification of the functional binding pocket for compounds targeting small-conductance Ca²⁺-activated potassium channels.

Nat. Commun. 3 , 1021, (2012)

Small- and intermediate-conductance Ca(2+)-activated potassium channels, activated by Ca(2+)-bound calmodulin, have an important role in regulating membrane excitability. These channels are also linke...

Synonyms

Synthalin sulfate

CyPPA

N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine

4-Pyrimidinamine, N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-

N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine

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