Introduction：Basic information about CAS 84477-87-2|H-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | H-7 |
|---|
| CAS Number | 84477-87-2 | Molecular Weight | 291.36900 |
|---|
| Density | 1.277 g/cm3 | Boiling Point | 495.3ºC at 760 mmHg |
|---|
| Molecular Formula | C14H17N3O2S | Melting Point | 114 °C |
|---|
| MSDS | ChineseUSA | Flash Point | 253.3ºC |
|---|
Names
| Name | 1-(5-isoquinolinesulfonyl)-2-methylpiperazine |
|---|
| Synonym | More Synonyms |
|---|
H-7 BiologicalActivity
| Description | Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1]. |
|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>PKCResearch Areas >>CancerSignaling Pathways >>TGF-beta/Smad >>PKC |
|---|
| Target | PKC:6 μM (Ki) |
|---|
| References | [1]. Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41. |
|---|
Chemical & Physical Properties
| Density | 1.277 g/cm3 |
|---|
| Boiling Point | 495.3ºC at 760 mmHg |
|---|
| Melting Point | 114 °C |
|---|
| Molecular Formula | C14H17N3O2S |
|---|
| Molecular Weight | 291.36900 |
|---|
| Flash Point | 253.3ºC |
|---|
| Exact Mass | 291.10400 |
|---|
| PSA | 70.68000 |
|---|
| LogP | 2.56470 |
|---|
| Index of Refraction | 1.652 |
|---|
| InChIKey | BDVFVCGFMNCYPV-UHFFFAOYSA-N |
|---|
| SMILES | CC1CNCCN1S(=O)(=O)c1cccc2cnccc12 |
|---|
| Storage condition | 2-8°C |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TL9305000
- CHEMICAL NAME :
- Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-
- CAS REGISTRY NUMBER :
- 84477-87-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C14-H17-N3-O2-S
- MOLECULAR WEIGHT :
- 291.40
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 94 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992- Volume(issue)/page/year: 30A,525,1994
|
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| WGK Germany | 3 |
|---|
| RTECS | TL9305000 |
|---|
| HS Code | 2935009090 |
|---|
Customs
| HS Code | 2935009090 |
|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
|---|
Articles44
More Articles
| Protein kinase A stimulates Kv7.1 surface expression by regulating Nedd4-2-dependent endocytic trafficking. Am. J. Physiol. Cell Physiol. 309 , C693-706, (2015) The potassium channel Kv7.1 plays critical physiological roles in both heart and epithelial tissues. In heart, Kv7.1 and the accessory subunit KCNE1 forms the slowly activating delayed-rectifier potas... | |
| Rho kinase inhibition by fasudil in the striatal 6-hydroxydopamine lesion mouse model of Parkinson disease. J. Neuropathol. Exp. Neurol. 73(8) , 770-9, (2014) Chronic degeneration of nigrostriatal projections, followed by nigral dopaminergic cell death, is a key feature of Parkinson disease (PD). This study examines the neuroprotective potential of the rho ... | |
| Co-receptors are dispensable for tethering receptor-mediated phagocytosis of apoptotic cells. Cell Death Dis. 6 , e1772, (2015) During efferocytosis, phagocytic cells recognize dying cells by receptors binding to ligands specifically exposed on apoptotic cells. Multiple phagocytic receptors and some of their signaling pathways... | |
Synonyms
| H-7 dihydrochloride,(±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazinedihydrochloride |
| H-7 |
| H-72HCl |
