CAS 872201-12-2|K 114

Introduction：Basic information about CAS 872201-12-2|K 114, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. K 114 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles1
6. Synonyms

Common Name	K 114
CAS Number	872201-12-2	Molecular Weight	393.27
Density	/	Boiling Point	/
Molecular Formula	C₂₂H₁₇BrO₂	Melting Point	/
MSDS	USA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	4-[(E)-2-[3-bromo-4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenyl]ethenyl]phenol
Synonym	More Synonyms

K 114 BiologicalActivity

Description	K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. LeVine H 3rd, et al. Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114). Biochemistry. 2005 Dec 6;44(48):15937-43.

Chemical & Physical Properties

Molecular Formula	C₂₂H₁₇BrO₂
Molecular Weight	393.27
Exact Mass	392.04100
PSA	40.46000
LogP	6.20110
InChIKey	OXPHQQMZTXMEGO-RJTULKDBSA-N
SMILES	Oc1ccc(C=Cc2ccc(C=Cc3ccc(O)cc3)c(Br)c2)cc1

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319-H413
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
RIDADR	NONH for all modes of transport

Articles1

Coaggregation of RNA-binding proteins in a model of TDP-43 proteinopathy with selective RGG motif methylation and a role for RRM1 ubiquitination.

PLoS ONE 7 , e38658, (2012)

TAR DNA-binding protein 43 (TDP-43) is a major component within ubiquitin-positive inclusions of a number of neurodegenerative diseases that increasingly are considered as TDP-43 proteinopathies. Iden...

Synonyms

k114

hms3263m09

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