Introduction：Basic information about CAS 902779-59-3|FPA 124, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | FPA 124 |
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| CAS Number | 902779-59-3 | Molecular Weight | 381.72500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C11H9Cl2CuN3O2S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | FPA 124,Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamidecoppercomplex |
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| Synonym | More Synonyms |
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FPA 124 BiologicalActivity
| Description | FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>Akt |
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| In Vitro | FPA-124 exhibits dose-dependent growth inhibitory effects with IC50s of 7, 10, 34, and 55 μM in BT20, PC-3, COLO 357 and BxPC-3 cancer cell lines, respectively[1]. |
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| In Vivo | FPA-124 exhibits PKB (Akt protein) inhibitory activities and causes NF-κB inactivation in a well-established orthotopic pancreatic tumor model using COLO 357 cells[1]. |
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| References | [1]. Barve V, et al. Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J Med Chem. 2006 Jun 29;49(13):3800-8. [2]. Biscetti F, et al. Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation. Cardiovasc Diabetol. 2009 Sep 8;8:49. |
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Chemical & Physical Properties
| Molecular Formula | C11H9Cl2CuN3O2S |
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| Molecular Weight | 381.72500 |
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| Exact Mass | 379.90900 |
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| PSA | 112.71000 |
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| LogP | 3.42780 |
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Synonyms
