CAS 143322-58-1|Eletriptan

Introduction：Basic information about CAS 143322-58-1|Eletriptan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Eletriptan BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Eletriptan
CAS Number	143322-58-1	Molecular Weight	382.519
Density	1.2±0.1 g/cm3	Boiling Point	613.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₂O₂S	Melting Point	/
MSDS	/	Flash Point	324.8±31.5 °C

Names

Name	eletriptan
Synonym	More Synonyms

Eletriptan BiologicalActivity

Description	Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[1].
Related Catalog	Research Areas >>Inflammation/ImmunologyResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
Target	5-HT1B Receptor:8.0 (pKi) 5-HT1D Receptor:8.9 (pKi)
In Vivo	Eletriptan (10, 30, 100, 300 and 1000 µg/kg; i.v.) reduces total carotid blood flow in anaesthetised pigs by selectively reducing carotid arteriovenous anastomotic blood flow and increasing nutrient blood flow within the carotid vascular bed[2].
References	[1]. McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66(8):1129-49. [2]. Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):212-9.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	613.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₂O₂S
Molecular Weight	382.519
Flash Point	324.8±31.5 °C
Exact Mass	382.171509
PSA	61.55000
LogP	3.08
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.634
InChIKey	PWVXXGRKLHYWKM-LJQANCHMSA-N
SMILES	CN1CCCC1Cc1c[nH]c2ccc(CCS(=O)(=O)c3ccccc3)cc12
Storage condition	Hygroscopic, Refrigerator, Under Inert Atmosphere

Synonyms

3-{[(2R)-1-Methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole

3-{[(2R)-1-Methyl-2-pyrrolidinyl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole

Eletriptan

MFCD00943792

1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-

5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole

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