Introduction：Basic information about CAS 70181-03-2|Dazopride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dazopride |
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| CAS Number | 70181-03-2 | Molecular Weight | 326.82200 |
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| Density | 1.27g/cm3 | Boiling Point | / |
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| Molecular Formula | C15H23ClN4O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-amino-5-chloro-N-(1,2-diethylpyrazolidin-4-yl)-2-methoxybenzamide |
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| Synonym | More Synonyms |
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Dazopride BiologicalActivity
| Description | Dazopride is an antiemetic agent. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
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| In Vivo | Dazopride (0.3 mg/kg) produces significant enhancement of gastric evacuation and is approximately six times more potent than metoclopramide in gastric evacuation assay. Dazopride (0.3-10.0 mg/kg, i.v.) produces a dose-related increase in antral motility primarily by increasing the amplitude of antral contractions in three conscious dogs. Dazopride significantly reduces the emetic frequency from that of the control group[1]. Dazopride (5 mg/kg, i.p.) antagonises the tetralin-induced emesis in all animals, but fails to antagonise the response at 0.25-2.5 mg/kg. Dazopride fails to modify cisplatin-induced emesis at 0.1 mg/kg (i.v,) although a larger dose of 1.0 mg/kg abolishes or attenuates the response and 5.0 mg/kg of dazopride antagonises the development ofemesis in all animals[2]. |
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| References | [1]. Alphin RS, et al. Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility. Dig Dis Sci. 1986 May;31(5):524-9. [2]. Costall B, et al. The action of dazopride to enhance gastric emptying and block emesis. Neuropharmacology. 1987 Jul;26(7A):669-77. |
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Chemical & Physical Properties
| Density | 1.27g/cm3 |
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| Molecular Formula | C15H23ClN4O2 |
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| Molecular Weight | 326.82200 |
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| Exact Mass | 326.15100 |
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| PSA | 70.83000 |
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| LogP | 2.44950 |
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| Index of Refraction | 1.6 |
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| InChIKey | YFXIKEZOBJFVAQ-UHFFFAOYSA-N |
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| SMILES | CCN1CC(NC(=O)c2cc(Cl)c(N)cc2OC)CN1CC |
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| Storage condition | 2-8℃ |
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Synonyms
| Dazopride |
| Dazopride [INN] |
| Dazopridum |
| 4-amino-5-chloro-N-(1,2-diethyl-pyrazolidin-4-yl)-2-methoxy-benzamide |
| Dazoprida |
| 4-amino-5-chloro-2-methoxy-N-(1,2-diethyl-4-pyrazolidinyl)benzamide |
| UNII-CV07VSP2G8 |
