CAS 3033-62-3|Bis(2-dimethylaminoethyl)ether

Introduction：Basic information about CAS 3033-62-3|Bis(2-dimethylaminoethyl)ether, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles3
7. Synonyms

Common Name	Bis(2-dimethylaminoethyl)ether
CAS Number	3033-62-3	Molecular Weight	160.257
Density	0.9±0.1 g/cm3	Boiling Point	194.8±15.0 °C at 760 mmHg
Molecular Formula	C₈H₂₀N₂O	Melting Point	/
MSDS	ChineseUSA	Flash Point	46.2±17.6 °C
Symbol	GHS05, GHS06	Signal Word	Danger

Names

Name	Bis(2-dimethylaminoethyl) ether
Synonym	More Synonyms

Chemical & Physical Properties

Density	0.9±0.1 g/cm3
Boiling Point	194.8±15.0 °C at 760 mmHg
Molecular Formula	C₈H₂₀N₂O
Molecular Weight	160.257
Flash Point	46.2±17.6 °C
Exact Mass	160.157562
PSA	15.71000
LogP	-1.44
Vapour Pressure	0.4±0.4 mmHg at 25°C
Index of Refraction	1.445
InChIKey	GTEXIOINCJRBIO-UHFFFAOYSA-N
SMILES	CN(C)CCOCCN(C)C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KR9460000

CHEMICAL NAME :: Ethylamine, 2,2'-oxybis(N,N-dimethyl-

CAS REGISTRY NUMBER :: 3033-62-3

BEILSTEIN REFERENCE NO. :: 1739668

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C8-H20-N2-O

MOLECULAR WEIGHT :: 160.30

WISWESSER LINE NOTATION :: 1N1&2 2O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,721,1986

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,3,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/27/1971

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,721,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,3,1986

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 117 ppm/6H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536387

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 280 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1540 mg/kg/7D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536157

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 ppm/6H/9D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - ptosis Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536526

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 292 mg/kg/11D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,3,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 391 mg/kg/13W-I

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,3,1986 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

DOSE :: 650 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

REFERENCE :: JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982- Volume(issue)/page/year: 5,263,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO BIS(2-(DIMETHYlAMINO)ETHYL)ETHER-air:minimize exposure REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0015 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 40 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0015 No. of Facilities: 60 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1529 (estimated) No. of Female Employees: 165 (estimated)

Safety Information

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H302-H311-H314-H332
Precautionary Statements	P280-P305 + P351 + P338-P310
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T: Toxic;
Risk Phrases	R22;R23/24;R34
Safety Phrases	S26-S36/37/39-S45
RIDADR	UN 2927 6.1/PG 2
WGK Germany	2
RTECS	KR9460000
Packaging Group	III
Hazard Class	3
HS Code	2922199090

Customs

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles3

Highly catalytic asymmetric addition of deactivated alkyl grignard reagents to aldehydes.

Org. Lett. 11 , 5578-5581, (2009)

Generally used and highly reactive RMgBr reagents were effectively deactivated by bis[2-(N,N-dimethylamino)ethyl] ether and then were employed in the highly enantioselective addition of Grignard reage...

The acute toxicity and irritancy of bis[2-(dimethylamino)ethyl]ether.

Vet. Hum. Toxicol. 39(5) , 290-5, (1997)

Bis[2-(dimethylamino)ethyl]ether (DMAEE; CAS No 3033-62-3) is an industrial liquid chemical used principally as an amine catalyst. It was investigated for potential acute hazards. DMAEE is of moderate...

Bis[2-(dimethylamino)ethyl]ether(CH3)2NCH2CH2OCH2CH2N(CH3)2.

J. Appl. Toxicol. 25(3) , 260-9, (2005)

Synonyms

2,2'-Oxybis(N,N-dimethylethanamine)

Bis(2-dimethylaminoethyl)ether

A 99

EINECS 221-220-5

Bis(2-(dimethylamino)ethyl) ether

niaxa99

Bis[2-(dimethylamino)ethyl] ether

Ethanamine, 2,2'-oxybis[N,N-dimethyl-

kalpurpc

Bis(2-diMethylaMinoethyl) Ether

A 133

dabcobl11

BDMAEE

MFCD00059199

ET 33B

Niax A 4

Niax A 1

Clavulanate Potassium Impurity 12

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