CAS 110101-66-1|Tirilazad

Introduction：Basic information about CAS 110101-66-1|Tirilazad, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tirilazad BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Tirilazad
CAS Number	110101-66-1	Molecular Weight	624.86
Density	1.25g/cm3	Boiling Point	812.9ºC at 760mmHg
Molecular Formula	C₃₈H₅₂N₆O₂	Melting Point	/
MSDS	/	Flash Point	445.4ºC

Names

Name	(8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
Synonym	More Synonyms

Tirilazad BiologicalActivity

Description	Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087. [2]. Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778. [3]. Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65.

Description

Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].

Related Catalog

Research Areas >>InfectionSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087.

[2]. Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778.

[3]. Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65.

Chemical & Physical Properties

Density	1.25g/cm3
Boiling Point	812.9ºC at 760mmHg
Molecular Formula	C₃₈H₅₂N₆O₂
Molecular Weight	624.86
Flash Point	445.4ºC
Exact Mass	624.41500
PSA	72.88000
LogP	5.59120
Vapour Pressure	1.71E-26mmHg at 25°C
Index of Refraction	1.646
InChIKey	RBKASMJPSJDQKY-RBFSKHHSSA-N
SMILES	CC1CC2C3CCC4=CC(=O)C=CC4(C)C3=CCC2(C)C1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1

Synonyms

Pregna-1,4,9(11)-triene-3,20-dione,21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)erazinyl)-16-methyl-,(16alpha)

tirilazad of tirilazad

Tirilazad

Tirilazad (INN)

Tirilazad [INN:BAN]

Tirilazadum

Tirilazadum [INN-Latin]

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