Introduction：Basic information about CAS 149488-17-5|Trovirdine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Trovirdine |
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| CAS Number | 149488-17-5 | Molecular Weight | 337.23800 |
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| Density | 1.539g/cm3 | Boiling Point | 450.6ºC at 760mmHg |
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| Molecular Formula | C13H13BrN4S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Trovirdine |
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| Synonym | More Synonyms |
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Trovirdine BiologicalActivity
| Description | Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.IC50 value: 7 nMTarget: HIV-1Trovirdine is currently in phase I clinical trials for potential use in thetreatment of AIDS. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection |
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| References | [1]. Zhang, H. et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethylthiazolyl thiourea derivatives trovirdine and MSC-127. [2]. Cantrell, A.S. et al. Phenethylthiazolylthiourea (PETT) compounds as a newclass of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs. |
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Chemical & Physical Properties
| Density | 1.539g/cm3 |
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| Boiling Point | 450.6ºC at 760mmHg |
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| Molecular Formula | C13H13BrN4S |
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| Molecular Weight | 337.23800 |
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| Exact Mass | 336.00400 |
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| PSA | 81.93000 |
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| LogP | 3.23210 |
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| Appearance of Characters | light yellow solid |
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| Vapour Pressure | 2.61E-08mmHg at 25°C |
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| Index of Refraction | 1.696 |
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| InChIKey | HOCFDYZWQYGULA-UHFFFAOYSA-N |
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| SMILES | S=C(NCCc1ccccn1)Nc1ccc(Br)cn1 |
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| Storage condition | -20℃ |
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Synonyms
| Thiourea,N-(5-bromo-2-pyridinyl)-N'-[2-(2-pyridinyl)ethyl] |
| Hi-142 |
| LY-300046 |
