Introduction：Basic information about CAS 1989-52-2|Cholesterol myristate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cholesterol myristate |
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| CAS Number | 1989-52-2 | Molecular Weight | 597.00900 |
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| Density | 0.95 g/cm3 | Boiling Point | 630.7ºC at 760 mmHg |
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| Molecular Formula | C41H72O2 | Melting Point | 84 °C |
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| MSDS | / | Flash Point | 334.8ºC |
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Names
| Name | cholesteryl myristate |
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| Synonym | More Synonyms |
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Cholesterol myristate BiologicalActivity
| Description | Cholesterol myristate is a natural steroid present in traditional Chinese medicine. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerNatural Products >>Steroids |
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| Target | Human Endogenous Metabolite |
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| In Vitro | Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1]. |
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| Cell Assay | MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured[1]. |
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| References | [1]. Chen DF, et al. Cholesterol myristate suppresses the apoptosis of mesenchymal stem cells via upregulation of inhibitor of differentiation. Steroids. 2010 Dec 12;75(13-14):1119-26. [2]. Chen DF, et al. BMP-Id pathway targeted by cholesterol myristate suppresses the apoptosis of PC12 cells. Brain Res. 2011 Jan 7;1367:33-42. |
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Chemical & Physical Properties
| Density | 0.95 g/cm3 |
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| Boiling Point | 630.7ºC at 760 mmHg |
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| Melting Point | 84 °C |
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| Molecular Formula | C41H72O2 |
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| Molecular Weight | 597.00900 |
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| Flash Point | 334.8ºC |
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| Exact Mass | 596.55300 |
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| PSA | 26.30000 |
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| LogP | 12.64070 |
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| Vapour Pressure | 8.15E-16mmHg at 25°C |
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| Index of Refraction | 1.506 |
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| InChIKey | SJDMTGSQPOFVLR-ZVMQTDSHSA-N |
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| SMILES | CCCCCCCCCCCCCC(=O)OC1CCC2(C)C(=CCC3C2CCC2(C)C(C(C)CCCC(C)C)CCC32)C1 |
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| Storage condition | −20°C |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | 26-36 |
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| WGK Germany | 3 |
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Synonyms
| Cholesterol=tetradecanoate |
| CHOLESTERYL TETRADODEDECANOATE |
| EINECS 217-867-8 |
| Cholesteryl myristate |
| Cholest-5-en-3-yl myristate |
| Cholesterol Myristate |
| Cholestryl myristate |
| MFCD00014256 |
| Myristic Acid Cholesterol Ester |
| O-myristoyl-cholesterol |
| cholesteryl tetradecanoate |
| Cholestryl myristic acid |
| Myristinsaeure-cholesterylester |
