Introduction：Basic information about CAS 115956-12-2|Dolasetron, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dolasetron |
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| CAS Number | 115956-12-2 | Molecular Weight | 324.37400 |
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| Density | 1.37 g/cm3 | Boiling Point | 535.1ºC at 760 mmHg |
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| Molecular Formula | C19H20N2O3 | Melting Point | 278 ºC |
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| MSDS | / | Flash Point | 277.4ºC |
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Names
| Name | (2alpha,6alpha,8alpha,9abeta)-Octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1H-indole-3-carboxylate |
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| Synonym | More Synonyms |
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Dolasetron BiologicalActivity
| Description | Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Others |
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| References | [1]. Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7(1):50-8. [2]. Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV). Support Care Cancer. 2014 Feb;22(2):469-77. |
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Chemical & Physical Properties
| Density | 1.37 g/cm3 |
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| Boiling Point | 535.1ºC at 760 mmHg |
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| Melting Point | 278 ºC |
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| Molecular Formula | C19H20N2O3 |
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| Molecular Weight | 324.37400 |
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| Flash Point | 277.4ºC |
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| Exact Mass | 324.14700 |
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| PSA | 62.40000 |
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| LogP | 2.45690 |
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| Vapour Pressure | 4.08E-10mmHg at 25°C |
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| Index of Refraction | 1.76 |
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| InChIKey | UKTAZPQNNNJVKR-UDXKHGJESA-N |
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| SMILES | O=C(OC1CC2CC3CC(C1)N2CC3=O)c1c[nH]c2ccccc12 |
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| Storage condition | Refrigerator |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . |
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| WGK Germany | 3 |
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Synonyms
| Dolasetronum [inn-latin] |
| Dolasetron |
| (2a,6a,8a,9ab)-1H-Indole-3-carboxylic acid,octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester |
| 1H-Indole-3-carboxylic acid,octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester,(2alpha,6alpha,8alpha,9abeta) |
| Dolasetronum |
| Octahydro-3-oxo-2,6-Methano-2H-quinolizin-8-yl Ester |
| Unii-82wi2L7Q6e |
