Introduction：Basic information about CAS 15727-65-8|1-Ethynylnaphthalene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Ethynylnaphthalene |
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| CAS Number | 15727-65-8 | Molecular Weight | 152.19200 |
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| Density | 1.070 g/mL at 25ºC(lit.) | Boiling Point | 270.4ºC at 760 mmHg |
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| Molecular Formula | C12H8 | Melting Point | / |
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| MSDS | / | Flash Point | 106.3ºC |
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Names
| Name | 1-ethynylnaphthalene |
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| Synonym | More Synonyms |
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1-Ethynylnaphthalene BiologicalActivity
| Description | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Research Areas >>Cancer |
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| Target | P450 1B1[1] |
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| In Vitro | 1-Ethynylnaphthalene, selective inhibitor of cytochrome P450 IB1, does not affect 2-hydroxylation but inhibits 4-hydroxylation by 38%. At higher concentrations, 1-Ethynylnaphthalene inhibits 2-hydroxylation of 2-Hydroxylation of estradiol (E2) by ~30% and 4-hydroxylation of E2 by up to 80%[1]. |
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| References | [1]. Liehr JG, et al. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9220-4. |
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Chemical & Physical Properties
| Density | 1.070 g/mL at 25ºC(lit.) |
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| Boiling Point | 270.4ºC at 760 mmHg |
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| Molecular Formula | C12H8 |
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| Molecular Weight | 152.19200 |
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| Flash Point | 106.3ºC |
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| Exact Mass | 152.06300 |
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| LogP | 2.82110 |
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| Vapour Pressure | 0.0114mmHg at 25°C |
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| Index of Refraction | n20/D 1.6500(lit.) |
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| InChIKey | MCZUXEWWARACSP-UHFFFAOYSA-N |
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| SMILES | C#Cc1cccc2ccccc12 |
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| Storage condition | 2-8℃ |
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Safety Information
| Risk Phrases | R10 |
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| Safety Phrases | 16 |
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| RIDADR | UN 1993 3 |
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| HS Code | 2902909090 |
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Customs
| HS Code | 2902909090 |
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| Summary | 2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0% |
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Synonyms
| 1-(ethynyl)naphthalene |
| 1-naphthalene-acetylene |
| Naphthalene,1-ethynyl |
| naphthylacetylene |
| (1-naphthyl)acetylene |
| MFCD02093737 |
| ethynyl-naphthalene |
