Introduction：Basic information about CAS 38819-10-2|Ara-G, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ara-G |
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| CAS Number | 38819-10-2 | Molecular Weight | 283.241 |
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| Density | 2.3±0.1 g/cm3 | Boiling Point | 775.9ºC at 760 mmHg |
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| Molecular Formula | C10H13N5O5 | Melting Point | 225°C(lit.) |
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| MSDS | / | Flash Point | 423.1ºC |
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Names
| Name | 9-β-D-arabinofuranosylguanine |
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| Synonym | More Synonyms |
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Ara-G BiologicalActivity
| Description | 9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| Target | Km: 8.0 μM (dGK)[2] |
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| In Vitro | 9-β-D-Arabinofuranosylguanine 通过其 5 ' -三磷酸腺苷 Ara-GTP 在细胞内的积累引起细胞毒性，Ara-GTP 抑制 DNA 聚合酶和核糖核苷酸还原酶，并入 DNA，终止 DNA 链伸长，导致细胞死亡[1][2]。 9-β-D-Arabinofuranosylguanine 对培养的 T 淋巴母细胞具有选择性毒性，因为相对于 B- 和无淋巴母细胞，它们能够积累更高水平的细胞毒性代谢物 Ara-GTP[1]。 9-β-D-Arabinofuranosylguanine (0-1000 μM; 72 h) 具有细胞毒性，对 MOLT-4、MOLT-4/Ara-G500 和 MOLT-4/Ara-G900 的 IC50 分别为 4.2、452 和 777 μM[2]。 Cell Viability Assay[2] Cell Line: MOLT-4 and Ara-G-resistant sublines: MOLT-4/Ara-G500 and MOLT-4/Ara-G900 Concentration: 0-1000 μM Incubation Time: 72 h Result: Showed cytotoxicity with IC50s of 4.2, 452 and 777 μM against MOLT-4, MOLT-4/Ara-G500 and MOLT-4/Ara-G900 cells, respectively. |
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| References | [1]. Shewach DS, et al. Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells. Cancer Res. 1989 Dec 1;49(23):6498-502. [2]. Lotfi K, et al. Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity. Biochem Biophys Res Commun. 2002 May 24;293(5):1489-96. |
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Chemical & Physical Properties
| Density | 2.3±0.1 g/cm3 |
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| Boiling Point | 775.9ºC at 760 mmHg |
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| Melting Point | 225°C(lit.) |
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| Molecular Formula | C10H13N5O5 |
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| Molecular Weight | 283.241 |
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| Flash Point | 423.1ºC |
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| Exact Mass | 283.091675 |
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| PSA | 159.51000 |
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| LogP | -1.72 |
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| Index of Refraction | 1.955 |
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| InChIKey | NYHBQMYGNKIUIF-FJFJXFQQSA-N |
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| SMILES | Nc1nc2c(ncn2C2OC(CO)C(O)C2O)c(=O)[nH]1 |
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| Storage condition | 2-8°C |
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| Water Solubility | DMSO: >10mg/mL |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MF8301000
- CHEMICAL NAME :
- Guanine, 9-(beta-D-arabinofuranosyl)-
- CAS REGISTRY NUMBER :
- 38819-10-2
- LAST UPDATED :
- 198806
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C10-H13-N5-O5
- MOLECULAR WEIGHT :
- 283.28
- WISWESSER LINE NOTATION :
- T56 BN DN FVM INJ HZ B1- BT5OTJ CQ DQ EQ -D, BETA, ARAB
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 50 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,1008,1985
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R22;R36/37/38 |
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| Safety Phrases | S26 |
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| RTECS | MF8301000 |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 9-beta-D-arabinofuranosylguanine |
| 2-Amino-9-(β-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one |
| Arabinosylguanine |
| Ara-G |
| 9-arabinofuranosylguanine |
| 9-b-D-Arabinofuranosylguanine |
| 6H-Purin-6-one, 2-amino-9-β-D-arabinofuranosyl-1,9-dihydro- |
| ARABINOFURANOSYL-GUANINE |
| 9-β-D-Arabinofuranosylguanine Hydrate |
| 9-Arabinoguanine |
| GUANINE-9-ARABINOSIDE |
