CAS 514-47-6|Euphol

Introduction：Basic information about CAS 514-47-6|Euphol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Euphol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Euphol
CAS Number	514-47-6	Molecular Weight	426.717
Density	1.0±0.1 g/cm3	Boiling Point	498.9±44.0 °C at 760 mmHg
Molecular Formula	C₃₀H₅₀O	Melting Point	116-117ºC
MSDS	/	Flash Point	221.1±20.7 °C

Names

Name	5.α.-Eupha-8,24-dien-3.β.-ol
Synonym	More Synonyms

Euphol BiologicalActivity

Description	Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain[1].
Related Catalog	Signaling Pathways >>Others >>Others
Target	IC50: 315 nM (monoacylglycerol lipase activity)[1]
In Vitro	Euphol (0.01-0.3 mM; 24-72 hours) markedly inhibits T47D cells proliferation, the IC50 values of euphol treatment for 24, 48 and 72 h were 0.26, 0.22 and 0.13 mM, respectively[2]. Euphol (0.03 mM; 48 or 72 hours) leads to cell cycle arrest by regulating expression of cell cycle-associated proteins[2]. Cell Proliferation Assay[2] Cell Line: T47D cells Concentration: 0.01, 0.03, 0.1 and 0.3 mM Incubation Time: 24, 48 and 72 hours Result: Decreased the percentage of viable cells. Western Blot Analysis[2] Cell Line: T47D cells Concentration: 0.03 mM Incubation Time: 48 and 72 hours Result: Increased the expression of p21 and p27, reduced the expression of cyclin A, B1 and D.
References	[1]. Dutra RC, et al. Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. Neuropharmacology. 2012 Sep;63(4):593-605. [2]. Wang L, et al. Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression. Mol Med Rep. 2013 Oct;8(4):1279-85.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	498.9±44.0 °C at 760 mmHg
Melting Point	116-117ºC
Molecular Formula	C₃₀H₅₀O
Molecular Weight	426.717
Flash Point	221.1±20.7 °C
Exact Mass	426.386169
PSA	20.23000
LogP	11.00
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.530
InChIKey	CAHGCLMLTWQZNJ-ZMBNEQANSA-N
SMILES	CC(C)=CCCC(C)C1CCC2(C)C3=C(CCC12C)C1(C)CCC(O)C(C)(C)C1CC3
Storage condition	-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OE3370000

CHEMICAL NAME :: Lanosta-8,24-dien-3-ol, (3-beta,13-alpha,14-beta,17-alpha)-

CAS REGISTRY NUMBER :: 514-47-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C30-H50-O

MOLECULAR WEIGHT :: 426.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 55,498,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 55,498,1989

Synonyms

13α,14β,17βH-Lanosta-8,24-dien-3β-ol (8CI)

Euphadienol

(3β,13α,14β,17α)-Lanosta-8,24-dien-3-ol

5α-Eupha-8,24-dien-3β-ol

Euphol, Euphadienol

euphol

Lanosta-8,24-dien-3-ol, (3β,13α,14β,17α)-

Recommended......