CAS 5128-44-9|7,4'-Di-O-methylapigenin

Introduction：Basic information about CAS 5128-44-9|7,4'-Di-O-methylapigenin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 7,4'-Di-O-methylapigenin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	7,4'-Di-O-methylapigenin
CAS Number	5128-44-9	Molecular Weight	298.290
Density	1.3±0.1 g/cm3	Boiling Point	515.2±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₄O₅	Melting Point	/
MSDS	/	Flash Point	193.3±23.6 °C

Names

Name	apigenin 7,4'-dimethyl ether
Synonym	More Synonyms

7,4'-Di-O-methylapigenin BiologicalActivity

Description	The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml).IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2]In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2]In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyNatural Products >>Flavonoids
References	[1]. Alvarez, M.E. et al.Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke.Farmaco. Jun-Jul;55(6-7):502-5.doi:10.1016/S0014-827X(00)00067-7(2000). [2]. Mangoyi, R., Midiwo, J. & Mukanganyama, S. Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. BMC complementary and alternative medicine 15, 405, doi:10.1186/s12906-015-0934-7 (2015).

Description

The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines.And it also showed inhibition of the drug efflux pumps (with IC50 = 51.64 μg/ml).IC50:51.64 μg/ml(Candida albicans drug efflux pumps)[2]In vitro: The isolated 7,4'-Di-O-methylapigenin was further investigated for its inhibitory activity on ABC drug efflux pumps in C. albicans by monitoring an increase in ciprofloxacin, assessing the level of its accumulation, in response to reserpine. There was a higher accumulation of ciprofloxacin in Candida cells in the presence of 7,4'-Di-O-methylapigenin than with reserpine. The compound 7,4'-Di-O-methylapigenine demonstrated the activity in a dose-dependent manner with IC50 value of 51.64 μg/ml. These results support those obtained from synergism assays where by the underlying synergistic antifungal mechanisms could be due to blockage of ABC efflux pumps and increasing the susceptibility of Candida to miconazole.[2]In vivo: In searching for natural products as potential anti-inflammatory agents, 7,4'-Di-O-methylapigenin wasn't evaluated in vivo for its ability to inhibit acute inflammation.[1]

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyNatural Products >>Flavonoids

References

[1]. Alvarez, M.E. et al.Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke.Farmaco. Jun-Jul;55(6-7):502-5.doi:10.1016/S0014-827X(00)00067-7(2000).

[2]. Mangoyi, R., Midiwo, J. & Mukanganyama, S. Isolation and characterization of an antifungal compound 5-hydroxy-7,4'-dimethoxyflavone from Combretum zeyheri. BMC complementary and alternative medicine 15, 405, doi:10.1186/s12906-015-0934-7 (2015).

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	515.2±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₄O₅
Molecular Weight	298.290
Flash Point	193.3±23.6 °C
Exact Mass	298.084137
PSA	68.90000
LogP	3.40
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.622
InChIKey	LZERJKGWTQYMBB-UHFFFAOYSA-N
SMILES	COc1ccc(-c2cc(=O)c3c(O)cc(OC)cc3o2)cc1
Storage condition	-20℃

Safety Information

HS Code	2914509090

Customs

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Synonyms

Genkwanin 4'-methyl ether

Flavone, 5-hydroxy-4',7-dimethoxy-

4',7-Dimethylapigenin

Apigenin dimethyl ether

7,4'-dimethylapigenin

5-Hydroxy-4',7-dimethoxyflavone

5-Hydroxy-4',7-dimethoxy-flavone

5-Hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

7,4'-di-O-methylapigenin

5-hydroxy-7-methoxy-2-(4-methoxyphenyl)chromen-4-one

Apigenin 7,4'-dimethyl ether

4H-1-Benzopyran-4-one, 5-hydroxy-7-methoxy-2- (4-methoxyphenyl)-

Apigenin 4',7-dimethyl ether

4H-1-Benzopyran-4-one, 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-

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