CAS 403-90-7|Tyrosine, 3-fluoro-
Introduction：Basic information about CAS 403-90-7|Tyrosine, 3-fluoro-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tyrosine, 3-fluoro- | ||
|---|---|---|---|
| CAS Number | 403-90-7 | Molecular Weight | 199.17900 |
| Density | 1.421g/cm3 | Boiling Point | 362.4ºC at 760mmHg |
| Molecular Formula | C9H10FNO3 | Melting Point | 276-280ºC |
| MSDS | ChineseUSA | Flash Point | 172.9ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3-fluorotyrosine |
|---|---|
| Synonym | More Synonyms |
Tyrosine, 3-fluoro- BiologicalActivity
| Description | 2-Amino-3-(3-fluoro-4-hydroxyphenyl)propanoic acid is a tyrosine derivative[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1]. |
| References | [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. |
Chemical & Physical Properties
| Density | 1.421g/cm3 |
|---|---|
| Boiling Point | 362.4ºC at 760mmHg |
| Melting Point | 276-280ºC |
| Molecular Formula | C9H10FNO3 |
| Molecular Weight | 199.17900 |
| Flash Point | 172.9ºC |
| Exact Mass | 199.06400 |
| PSA | 83.55000 |
| LogP | 1.18600 |
| Vapour Pressure | 6.94E-06mmHg at 25°C |
| Index of Refraction | 1.591 |
| InChIKey | VIIAUOZUUGXERI-UHFFFAOYSA-N |
| SMILES | NC(Cc1ccc(O)c(F)c1)C(=O)O |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong reducing agents, strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 68,1671,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9900 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 155,135,1967
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn,T |
| Risk Phrases | 20/21/22 |
| Safety Phrases | S24/25 |
| RIDADR | UN 3276 |
| WGK Germany | 3 |
| RTECS | YP2660000 |
| Packaging Group | II |
| Hazard Class | 6.1 |
| HS Code | 2922509090 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles28
More Articles| Aminoacrylate intermediates in the reaction of Citrobacter freundii tyrosine phenol-lyase. Biochemistry 45(31) , 9575-83, (2006) Tyrosine phenol-lyase (TPL) from Citrobacter freundii is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the reversible hydrolytic cleavage of l-Tyr to give phenol and ammonium pyruvate... | |
| Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine. Biophys. J. 89(6) , 4171-9, (2005) Incorporation of 3-fluorotyrosine and site-specific mutagenesis has been utilized with Fourier transform infrared (FTIR) spectroscopy and x-ray crystallography to elucidate active-site structure and t... | |
| Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine. J. Mol. Biol. 281(2) , 323-39, (1998) The structure of the tetradeca-(3-fluorotyrosyl) M1-1 GSH transferase (3-FTyr GSH transferase), a protein in which tyrosine residues are globally substituted by 3-fluorotyrosines has been determined a... |
Synonyms
| 2-Amino-3-(3-fluoro-4-hydroxyphenyl)propanoic acid |
| MFCD00063075 |
| FLUORTHYRIN |
| PARDINON |
| DL-M-FLUOROTYROSINE |
| ba2745 |
| DL-3-FLUOROTYROSINE |
| m-fluorotyrosine |
| m-ftyr |
| H-3-FLUORO-DL-TYR-OH |
| EINECS 206-964-0 |
| 3-FLUORO-TYROSINE |
| Tyrosine, 3-fluoro- |
| rac-3-Fluorotyrosine |
| M-FLUORO-DL-TYROSINE |
| 3'-fluoro-DL-tyrosine |
