Introduction：Basic information about CAS 115-33-3|Oxyphenisatin acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxyphenisatin acetate |
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| CAS Number | 115-33-3 | Molecular Weight | 401.41100 |
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| Density | 1.282 g/cm3 | Boiling Point | 566.5ºC at 760 mmHg |
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| Molecular Formula | C24H19NO5 | Melting Point | 244℃ |
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| MSDS | / | Flash Point | 296.4ºC |
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Names
| Name | [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate |
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| Synonym | More Synonyms |
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Oxyphenisatin acetate BiologicalActivity
| Description | Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Others |
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| In Vitro | Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction[1]. |
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| In Vivo | Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model[1]. |
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| Animal Admin | Assessment in several other tumor models demonstrates tolerability with oxyphenisatin acetate at 300 mg/kg given once daily or 200 mg/kg given twice daily. For the MCF-7 study treatments are administered on an exact body weight basis using dose volumes of 1-2 mL/kg body weight. The vehicle control receives 100% DMSO. The treated group receives 300 mg/kg oxyphenisatin acetate once daily for a total of 10 days, followed by a 3 day rest and an additional 6 days of dosing. The dose solutions are prepared in 100% DMSO, aliquoted and stored frozen until used. The mice are monitored for a total of 52 days with treatment initiation occurring on day 27 posttumor implantation[1]. |
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| References | [1]. Morrison BL, et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700. |
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Chemical & Physical Properties
| Density | 1.282 g/cm3 |
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| Boiling Point | 566.5ºC at 760 mmHg |
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| Melting Point | 244℃ |
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| Molecular Formula | C24H19NO5 |
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| Molecular Weight | 401.41100 |
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| Flash Point | 296.4ºC |
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| Exact Mass | 401.12600 |
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| PSA | 81.70000 |
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| LogP | 3.96170 |
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| Vapour Pressure | 7.5E-13mmHg at 25°C |
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| Index of Refraction | 1.611 |
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| InChIKey | PHPUXYRXPHEJDF-UHFFFAOYSA-N |
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| SMILES | CC(=O)Oc1ccc(C2(c3ccc(OC(C)=O)cc3)C(=O)Nc3ccccc32)cc1 |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2933790090 |
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| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |
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Synonyms
| 3,3-bis-(4-acetoxy-phenyl)-indolin-2-one |
| Izafenin |
| 3,3-bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one |
| Darmoletten |
| Diphesatine |
| Acetalax |
| Contax |
| Promassolax |
| 3,3-bis(4-acetoxyphenyl)oxindole |
| Brocatine |
| Isaphenin |
| OXYPHENISATIN ACETATE |
| EINECS 204-083-6 |
| Diphesatin |
| 3,3-Bis-(4-acetoxy-phenyl)-indolin-2-on |
| oxyphenisatine di(acetate) |
